Total Synthesis and Structural Revision of Antibiotic CJ-16,264
Shah, Akshay A.
Theodorakis, Emmanuel A.
The total synthesis and structural revision of antibiotic CJ-16,264 is described. Starting with citronellal, the quest for the target molecule featured a novel bis-transannular Diels-Alder reaction that casted stereoselectively the decalin system and included the synthesis of six isomers before demystification of its true structure.
antibiotic; natural products; structural revision; total synthesis; transannular Diels-Alder reaction