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dc.contributor.authorPoulose, Aby Cheruvathoor
Veeranarayanan, Srivani
Mohamed, M. Sheikh
Nagaoka, Yutaka
Aburto, Rebeca Romero
Mitcham, Trevor
Ajayan, Pulickel M.
Bouchard, Richard R.
Sakamoto, Yasushi
Yoshida, Yasuhiko
Maekawa, Toru
Kumar, D. Sakthi
dc.date.accessioned 2016-08-30T20:50:15Z
dc.date.available 2016-08-30T20:50:15Z
dc.date.issued 2015
dc.identifier.citation Poulose, Aby Cheruvathoor, Veeranarayanan, Srivani, Mohamed, M. Sheikh, et al.. "Multi-stimuli responsive Cu2S nanocrystals as trimodal imaging and synergistic chemo-photothermal therapy agents." Nanoscale, 7, (2015) Royal Society of Chemistry: 8378-8388. http://dx.doi.org/10.1039/C4NR07139E.
dc.identifier.urihttps://hdl.handle.net/1911/91373
dc.description.abstract A size and shape tuned, multifunctional metal chalcogenide, Cu2S-based nanotheranostic agent is developed for trimodal imaging and multimodal therapeutics against brain cancer cells. This theranostic agent was highly efficient in optical, photoacoustic and X-ray contrast imaging systems. The folate targeted NIR-responsive photothermal ablation in synergism with the chemotherapeutic action of doxorubicin proved to be a rapid precision guided cancer-killing module. The multi-stimuli, i.e., pH-, thermo- and photo-responsive drug release behavior of the nanoconjugates opens up a wider corridor for on-demand triggered drug administration. The simple synthesis protocol, combined with the multitudes of interesting features packed into a single nanoformulation, clearly demonstrates the competing role of this Cu2S nanosystem in future cancer treatment strategies.
dc.language.iso eng
dc.publisher Royal Society of Chemistry
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the Royal Society of Chemistry.
dc.title Multi-stimuli responsive Cu2S nanocrystals as trimodal imaging and synergistic chemo-photothermal therapy agents
dc.type Journal article
dc.citation.journalTitle Nanoscale
dc.citation.volumeNumber 7
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1039/C4NR07139E
dc.identifier.pmcid PMC4528641
dc.identifier.pmid 25797920
dc.type.publication post-print
dc.citation.firstpage 8378
dc.citation.lastpage 8388


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