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dc.contributor.authorHernández-Rivera, Mayra
Zaibaq, Nicholas G.
Wilson, Lon J.
dc.date.accessioned 2016-07-21T20:14:36Z
dc.date.available 2016-07-21T20:14:36Z
dc.date.issued 2016
dc.identifier.citation Hernández-Rivera, Mayra, Zaibaq, Nicholas G. and Wilson, Lon J.. "Toward carbon nanotube-based imaging agents for the clinic." Biomaterials, 101, (2016) Elsevier: 229-240. http://dx.doi.org/10.1016/j.biomaterials.2016.05.045.
dc.identifier.urihttps://hdl.handle.net/1911/90940
dc.description.abstract Among the many applications for carbon nanotubes (CNTs), their use in medicine has drawn special attention due to their potential for a variety of therapeutic and diagnostic applications. As progress toward clinical applications continues, monitoring CNTs in vivowill be essential to evaluate their biodistribution, potential toxicity, therapeutic activity, and any physiological changes that the material may induce in specific tissues. There are many different imaging modalities to visualize and track CNTs in vivo, yet only a few are full-body penetrating, a central characteristic that widens their clinical utility. In order to visualize CNTs, chemical modification is often required for the material to be used as a platform to carry imaging agents compatible with one or more of the clinical imaging techniques. Here, we focus on the most recent work involving the use of CNTs as imaging agents for the non-invasive, full-body penetrating clinical modalities of MRI, PET, SPECT, and X-ray CT. The synthesis and modification of the CNT materials are discussed, as well as relevant preclinical studies.
dc.language.iso eng
dc.publisher Elsevier
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.
dc.title Toward carbon nanotube-based imaging agents for the clinic
dc.type Journal article
dc.citation.journalTitle Biomaterials
dc.contributor.org Smalley-Curl Institute
dc.subject.keywordcarbon nanotubes
clinical imaging
MRI
PET
SPECT
X-ray CT
dc.citation.volumeNumber 101
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1016/j.biomaterials.2016.05.045
dc.type.publication post-print
dc.citation.firstpage 229
dc.citation.lastpage 240


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