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dc.contributor.authorManchon, Jose Felix Moruno
Dabaghian, Yuri
Uzor, Ndidi-Ese
Kesler, Shelli R.
Wefel, Jeffrey S.
Tsvetkov, Andrey S.
dc.date.accessioned 2016-07-07T21:09:20Z
dc.date.available 2016-07-07T21:09:20Z
dc.date.issued 2016
dc.identifier.citation Manchon, Jose Felix Moruno, Dabaghian, Yuri, Uzor, Ndidi-Ese, et al.. "Levetiracetam mitigates doxorubicin-induced DNA and synaptic damage in neurons." Scientific Reports, 6, (2016) Springer Nature: http://dx.doi.org/10.1038/srep25705.
dc.identifier.urihttps://hdl.handle.net/1911/90836
dc.description.abstract Neurotoxicity may occur in cancer patients and survivors during or after chemotherapy. Cognitive deficits associated with neurotoxicity can be subtle or disabling and frequently include disturbances in memory, attention, executive function and processing speed. Searching for pathways altered by anti-cancer treatments in cultured primary neurons, we discovered that doxorubicin, a commonly used anti-neoplastic drug, significantly decreased neuronal survival. The drug promoted the formation of DNA double-strand breaks in primary neurons and reduced synaptic and neurite density. Pretreatment of neurons with levetiracetam, an FDA-approved anti-epileptic drug, enhanced survival of chemotherapy drug-treated neurons, reduced doxorubicin-induced formation of DNA double-strand breaks, and mitigated synaptic and neurite loss. Thus, levetiracetam might be part of a valuable new approach for mitigating synaptic damage and, perhaps, for treating cognitive disturbances in cancer patients and survivors.
dc.language.iso eng
dc.publisher Springer Nature
dc.rights This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. ᅠ
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.title Levetiracetam mitigates doxorubicin-induced DNA and synaptic damage in neurons
dc.type Journal article
dc.citation.journalTitle Scientific Reports
dc.citation.volumeNumber 6
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1038/srep25705
dc.identifier.pmcid PMC4863375
dc.identifier.pmid 27168474
dc.type.publication publisher version
dc.citation.articleNumber 25705


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