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    Modularity enhances the rate of evolution in a rugged fitness landscape

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    Author
    Park, Jeong-Man; Chen, Man; Wang, Dong; Deem, Michael W.
    Date
    2015
    Abstract
    Biological systems are modular, and this modularity affects the evolution of biological systems over time and in different environments. We here develop a theory for the dynamics of evolution in a rugged, modular fitness landscape. We show analytically how horizontal gene transfer couples to the modularity in the system and leads to more rapid rates of evolution at short times. The model, in general, analytically demonstrates a selective pressure for the prevalence of modularity in biology. We use this model to show how the evolution of the influenza virus is affected by the modularity of the proteins that are recognized by the human immune system. Approximately 25% of the observed rate of fitness increase of the virus could be ascribed to a modular viral landscape.
    Citation
    Park, Jeong-Man, Chen, Man, Wang, Dong, et al.. "Modularity enhances the rate of evolution in a rugged fitness landscape." Physical Biology, 12, no. 2 (2015) IOP Publishing Ltd: 025001. http://dx.doi.org/10.1088/1478-3975/12/2/025001.
    Published Version
    http://dx.doi.org/10.1088/1478-3975/12/2/025001
    Type
    Journal article
    Publisher
    IOP Publishing Ltd
    Citable link to this page
    https://hdl.handle.net/1911/90565
    Rights
    This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by IOP Publishing Ltd.
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    • Bioengineering Publications [631]
    • Faculty Publications [4976]
    • Physics and Astronomy Publications [1769]

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    Home | FAQ | Contact Us | Privacy Notice | Accessibility Statement
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
    Site Map