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dc.contributor.authorJia, Dongya
Jolly, Mohit Kumar
Boareto, Marcelo
Parsana, Princy
Mooney, Steven M.
Pienta, Kenneth J.
Levine, Herbert
Ben-Jacob, Eshel
dc.date.accessioned 2016-06-22T16:28:31Z
dc.date.available 2016-06-22T16:28:31Z
dc.date.issued 2015
dc.identifier.citation Jia, Dongya, Jolly, Mohit Kumar, Boareto, Marcelo, et al.. "OVOL guides the epithelial-hybrid-mesenchymal transition." Oncotarget, 6, no. 17 (2015) Impact Journals, LLC: 15436-15448. http://dx.doi.org/10.18632/oncotarget.3623.
dc.identifier.urihttps://hdl.handle.net/1911/90519
dc.description.abstract Metastasis involves multiple cycles of Epithelial-to-Mesenchymal Transition (EMT) and its reverse-MET. Cells can also undergo partial transitions to attain a hybrid epithelial/mesenchymal (E/M) phenotype that has maximum cellular plasticity and allows migration of Circulating Tumor Cells (CTCs) as a cluster. Hence, deciphering the molecular players helping to maintain the hybrid E/M phenotype may inform anti-metastasis strategies. Here, we devised a mechanism-based mathematical model to couple the transcription factor OVOL with the core EMT regulatory network miR-200/ZEB that acts as a three-way switch between the E, E/M and M phenotypes. We show that OVOL can modulate cellular plasticity in multiple ways - restricting EMT, driving MET, expanding the existence of the hybrid E/M phenotype and turning both EMT and MET into two-step processes. Our theoretical framework explains the differences between the observed effects of OVOL in breast and prostate cancer, and provides a platform for investigating additional signals during metastasis.asis.
dc.language.iso eng
dc.publisher Impact Journals, LLC
dc.rights All content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.title OVOL guides the epithelial-hybrid-mesenchymal transition
dc.type Journal article
dc.citation.journalTitle Oncotarget
dc.contributor.org Center for Theoretical Biological Physics
dc.subject.keywordEMT
metastasis
OVOL
partial EMT
cancer systems biology
dc.citation.volumeNumber 6
dc.citation.issueNumber 17
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.18632/oncotarget.3623
dc.identifier.pmcid PMC4558162
dc.identifier.pmid 25944618
dc.type.publication publisher version
dc.citation.firstpage 15436
dc.citation.lastpage 15448


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