Rice Univesrity Logo
    • FAQ
    • Deposit your work
    • Login
    View Item 
    •   Rice Scholarship Home
    • Rice University Graduate Electronic Theses and Dissertations
    • Rice University Electronic Theses and Dissertations
    • View Item
    •   Rice Scholarship Home
    • Rice University Graduate Electronic Theses and Dissertations
    • Rice University Electronic Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Hormonal and radiation effects on osteoclastic proliferation

    Thumbnail
    Name:
    RICE0512.pdf
    Size:
    5.547Mb
    Format:
    PDF
    View/Open
    Author
    Doty, Stephen Bruce
    Date
    1963
    Advisor
    Talmage, Roy V.
    Degree
    Master of Arts
    Abstract
    The past century of research on bone physiology has established that the osteoclast is involved in the resorption of bone. The presence of parathyroid hormone in the circulating body fluids causes the calcium concentration in these fluids to increase and there is an accompanying increase in osteoclastic activity in the bone tissue. The metabolic processes, which result in crystal removal from bone, are mediated by parathyroid activity and are necessary for maintenance of specific calcium levels in all land-dwelling vertebrates. This study shows various hormonal and radiation effects on osteoclastic proliferation and the relationship between the activity of these cells and the maintenance of calcium concentrations in the rat. The proliferation of the osteoclasts was produced by the technique of continuous peritoneal lavage and/or nephrectomy. The experimental work consisted of: (1) altering the circulating calcium concentration by acidosis, peritoneal administration of NeF, or supplying exogenous calcium; (2) studying the effects of hypophysectomy, adrenalectomy or estrogen administration to male rats; and (3) producing changes in bone by internal radiation with Ca45 or Pu239. The results show that although wide variations are found ia the osteoclast numbers produced by the various experimental conditions, the calcium levels are uniformly maintained. This would indicate either a constantly changing level of parathyroid activity, a change in activity of the osteoclasts present, or that the calcium concentration in the body fluids can be maintained without the necessity of osteoclastic proliferation.
    Citation
    Doty, Stephen Bruce. "Hormonal and radiation effects on osteoclastic proliferation." (1963) Master’s Thesis, Rice University. https://hdl.handle.net/1911/89482.
    Metadata
    Show full item record
    Collections
    • Rice University Electronic Theses and Dissertations [13128]

    Home | FAQ | Contact Us | Privacy Notice
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
    Site Map

     

    Searching scope

    Browse

    Entire ArchiveCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsTypeThis CollectionBy Issue DateAuthorsTitlesSubjectsType

    My Account

    Login

    Statistics

    View Usage Statistics

    Home | FAQ | Contact Us | Privacy Notice
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
    Site Map