Show simple item record

dc.contributor.authorKumar, Vivek A.
Taylor, Nichole L.
Jalan, Abhishek A.
Hwang, Lyahn K.
Wang, Benjamin K.
Hartgerink, Jeffrey D.
dc.date.accessioned 2016-04-05T20:14:03Z
dc.date.available 2016-04-05T20:14:03Z
dc.date.issued 2014
dc.identifier.citation Kumar, Vivek A., Taylor, Nichole L., Jalan, Abhishek A., et al.. "A Nanostructured Synthetic Collagen Mimic for Hemostasis." Biomacromolecules, 15, no. 4 (2014) American Chemical Society: 1484-1490. http://dx.doi.org/10.1021/bm500091e.
dc.identifier.urihttps://hdl.handle.net/1911/88852
dc.description.abstract Collagen is a major component of the extracellular matrix and plays a wide variety of important roles in blood clotting, healing, and tissue remodeling. Natural, animal derived, collagen is used in many clinical applications but concerns exist with respect to its role in inflammation, batch-to-batch variability, and possible disease transfection. Therefore, development of synthetic nanomaterials that can mimic the nanostructure and properties of natural collagen has been a heavily pursued goal in biomaterials. Previously, we reported on the design and multihierarchial self-assembly of a 36 amino acid collagen mimetic peptide (KOD) that forms nanofibrous triple helices that entangle to form a hydrogel. In this report, we utilize this nanofiber forming collagen mimetic peptide as a synthetic biomimetic matrix useful in thrombosis. We demonstrate that nanofibrous KOD synthetic collagen matrices adhere platelets, activate them (indicated by soluble P-selectin secretion), and clot plasma and blood similar to animal derived collagen and control surfaces. In addition to the thrombotic potential, THP-1 monocytes incubated with our KOD collagen mimetic showed minimal proinflammatory cytokine (TNF-α or IL-1β) production. Together, the data presented demonstrates the potential of a novel synthetic collagen mimetic as a hemostat.
dc.language.iso eng
dc.publisher American Chemical Society
dc.rights This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
dc.rights.urihttp://pubs.acs.org/page/policy/authorchoice_termsofuse.html
dc.title A Nanostructured Synthetic Collagen Mimic for Hemostasis
dc.type Journal article
dc.contributor.funder National Institutes of Health
dc.contributor.funder Welch Foundation
dc.contributor.funder National Science Foundation
dc.citation.journalTitle Biomacromolecules
dc.citation.volumeNumber 15
dc.citation.issueNumber 4
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1021/bm500091e
dc.identifier.pmcid PMC3993945
dc.identifier.pmid 24694012
dc.identifier.grantID R01 DE021798 (National Institutes of Health)
dc.identifier.grantID DMR-1206899 (National Science Foundation)
dc.identifier.grantID C-1557 (Welch Foundation)
dc.identifier.grantID F32 DE023696 (National Institutes of Health)
dc.type.publication publisher version
dc.citation.firstpage 1484
dc.citation.lastpage 1490


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record