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dc.contributor.authorHsu, Chih-Wei
Poché, Ross A.
Saik, Jennifer E.
Ali, Saniya
Wang, Shang
Yosef, Nejla
Calderon, Gisele A.
Scott, Larry Jr.
Vadakkan, Tegy J.
Larina, Irina V.
West, Jennifer L.
Dickinson, Mary E.
dc.date.accessioned 2016-04-01T20:24:37Z
dc.date.available 2016-04-01T20:24:37Z
dc.date.issued 2015
dc.identifier.citation Hsu, Chih-Wei, Poché, Ross A., Saik, Jennifer E., et al.. "Improved Angiogenesis in Response to Localized Delivery of Macrophage-Recruiting Molecules." PLoS ONE, 10, no. 7 (2015) Public Library of Science: e0131643. http://dx.doi.org/10.1371/journal.pone.0131643.
dc.identifier.urihttps://hdl.handle.net/1911/88821
dc.description.abstract Successful engineering of complex organs requires improved methods to promote rapid and stable vascularization of artificial tissue scaffolds. Toward this goal, tissue engineering strategies utilize the release of pro-angiogenic growth factors, alone or in combination, from biomaterials to induce angiogenesis. In this study we have used intravital microscopy to define key, dynamic cellular changes induced by the release of pro-angiogenic factors from polyethylene glycol diacrylate hydrogels transplanted in vivo. Our data show robust macrophage recruitment when the potent and synergistic angiogenic factors, PDGFBB and FGF2 were used as compared with VEGF alone and intravital imaging suggested roles for macrophages in endothelial tip cell migration and anastomosis, as well as pericyte-like behavior. Further data from in vivo experiments show that delivery of CSF1 with VEGF can dramatically improve the poor angiogenic response seen with VEGF alone. These studies show that incorporating macrophage-recruiting factors into the design of pro-angiogenic biomaterial scaffolds is a key strategy likely to be necessary for stable vascularization and survival of implanted artificial tissues.
dc.language.iso eng
dc.publisher Public Library of Science
dc.rights This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.title Improved Angiogenesis in Response to Localized Delivery of Macrophage-Recruiting Molecules
dc.type Journal article
dc.contributor.funder National Institutes of Health
dc.contributor.funder Cancer Prevention Research Institute of Texas
dc.contributor.funder American Heart Association Predoctoral Fellowship
dc.citation.journalTitle PLoS ONE
dc.citation.volumeNumber 10
dc.citation.issueNumber 7
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0131643
dc.identifier.pmcid PMC4489184
dc.identifier.pmid 26132702
dc.identifier.grantID R01HL097520-01A1 (National Institutes of Health)
dc.identifier.grantID R21EY020632 (National Institutes of Health)
dc.identifier.grantID RP120713-P3 (Cancer Prevention Research Institute of Texas)
dc.identifier.grantID 12PRE12030410 ( American Heart Association Predoctoral Fellowship)
dc.identifier.grantID F32EY019436 (National Institutes of Health)
dc.identifier.grantID R01HL120140 (National Institutes of Health)
dc.type.publication publisher version
dc.citation.firstpage e0131643


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This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Except where otherwise noted, this item's license is described as This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited