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dc.contributor.advisor Kelly, Kevin
dc.creatorWeng, Sheng
dc.date.accessioned 2016-02-05T22:05:58Z
dc.date.available 2016-02-05T22:05:58Z
dc.date.created 2015-05
dc.date.issued 2015-04-28
dc.date.submitted May 2015
dc.identifier.citation Weng, Sheng. "Label-free Imaging of Thyroid and Parathyroid Glands Using Coherent Anti-Stokes Raman Scattering (CARS) Microscopy." (2015) Master’s Thesis, Rice University. https://hdl.handle.net/1911/88429.
dc.identifier.urihttps://hdl.handle.net/1911/88429
dc.description.abstract Thyroid and parathyroid glands play a vital role in regulating the body's metabolism and calcium levels. Surgical removal of the glands is the main treatment for both thyroid cancer and parathyroid adenoma. In thyroidectomy and parathyroidectomy, it's very important to differentiate thyroid, parathyroid, and the other tissues around the neck. Traditionally, physicians use ultrasound guided fine needle aspiration (FNA) to evaluate thyroid nodules, but up to 30% of FNA results are “inconclusive”. The sestamibi scan can localize parathyroid adenoma, but currently it only has 50% accuracy. Here we applied the emerging CARS technique to image both thyroid and parathyroid tissues, which has potential to be used in real-time in vivo examination of different structures. We also developed algorithms to differentiate different cellular structures based on CARS images. When incorporated with a fiber optic endoscope in the future, CARS imaging technique can help surgeons identify cancerous thyroid tissue intraoperatively, preserve good parathyroid glands during thyroidectomy and find parathyroid adenoma during parathyroidectomy.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.subjectCARS imaging
Thyroid
Parathyroid
Nuclei segmentation
dc.title Label-free Imaging of Thyroid and Parathyroid Glands Using Coherent Anti-Stokes Raman Scattering (CARS) Microscopy
dc.contributor.committeeMember Wong, Stephen
dc.contributor.committeeMember Thomann, Isabell
dc.contributor.committeeMember Kono, Junichiro
dc.date.updated 2016-02-05T22:05:58Z
dc.type.genre Thesis
dc.type.material Text
thesis.degree.department Applied Physics
thesis.degree.discipline Engineering
thesis.degree.grantor Rice University
thesis.degree.level Masters
thesis.degree.name Master of Science
thesis.degree.major Applied Physics/Electrical Eng


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