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dc.contributor.authorPark, Jeong-Man
Niestemski, Liang Ren
Deem, Michael W.
dc.date.accessioned 2016-02-05T18:38:32Z
dc.date.available 2016-02-05T18:38:32Z
dc.date.issued 2015
dc.identifier.citation Park, Jeong-Man, Niestemski, Liang Ren and Deem, Michael W.. "Quasispecies theory for evolution of modularity." Physical Review E, 91, no. 1 (2015) American Physical Society: 012714. http://dx.doi.org/10.1103/PhysRevE.91.012714.
dc.identifier.urihttps://hdl.handle.net/1911/88398
dc.description.abstract Biological systems are modular, and this modularity evolves over time and in different environments. A number of observations have been made of increased modularity in biological systems under increased environmental pressure. We here develop a quasispecies theory for the dynamics of modularity in populations of these systems. We show how the steady-state fitness in a randomly changing environment can be computed. We derive a fluctuation dissipation relation for the rate of change of modularity and use it to derive a relationship between rate of environmental changes and rate of growth of modularity. We also find a principle of least action for the evolved modularity at steady state. Finally, we compare our predictions to simulations of protein evolution and find them to be consistent.
dc.language.iso eng
dc.publisher American Physical Society
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.title Quasispecies theory for evolution of modularity
dc.type Journal article
dc.contributor.funder National Institutes of Health
dc.contributor.funder Catholic University of Korea research fund 2014
dc.contributor.funder National Research Foundation of Korea
dc.citation.journalTitle Physical Review E
dc.citation.volumeNumber 91
dc.citation.issueNumber 1
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1103/PhysRevE.91.012714
dc.identifier.pmcid PMC4477872
dc.identifier.pmid 25679649
dc.identifier.grantID R01 GM 100468–01 (National Institutes of Health)
dc.identifier.grantID NRF-2011-013-C00029 (National Research Foundation of Korea)
dc.identifier.grantID NRF-2013R1A1A2006983 (National Research Foundation of Korea)
dc.type.publication publisher version
dc.citation.firstpage 012714


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