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dc.contributor.authorZhang, David Yu
Hariadi, Rizal F.
Choi, Harry M.T.
Winfree, Erik
dc.date.accessioned 2016-02-02T21:22:53Z
dc.date.available 2016-02-02T21:22:53Z
dc.date.issued 2013
dc.identifier.citation Zhang, David Yu, Hariadi, Rizal F., Choi, Harry M.T., et al.. "Integrating DNA strand-displacement circuitry with DNA tile self-assembly." Nature Communications, 4, (2013) Macmillan Publishers Limited: http://dx.doi.org/10.1038/ncomms2965.
dc.identifier.urihttps://hdl.handle.net/1911/88317
dc.description.abstract DNA nanotechnology has emerged as a reliable and programmable way of controlling matter at the nanoscale through the specificity of Watson–Crick base pairing, allowing both complex self-assembled structures with nanometer precision and complex reaction networks implementing digital and analog behaviors. Here we show how two well-developed frameworks, DNA tile self-assembly and DNA strand-displacement circuits, can be systematically integrated to provide programmable kinetic control of self-assembly. We demonstrate the triggered and catalytic isothermal self-assembly of DNA nanotubes over 10 μm long from precursor DNA double-crossover tiles activated by an upstream DNA catalyst network. Integrating more sophisticated control circuits and tile systems could enable precise spatial and temporal organization of dynamic molecular structures.
dc.language.iso eng
dc.publisher Macmillan Publishers Limited
dc.rights This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.title Integrating DNA strand-displacement circuitry with DNA tile self-assembly
dc.type Journal article
dc.contributor.funder National Science Foundation
dc.contributor.funder Hertz Foundation graduate fellowship
dc.contributor.funder Life Sciences Research Foundation
dc.contributor.funder National Institutes of Health
dc.citation.journalTitle Nature Communications
dc.citation.volumeNumber 4
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1038/ncomms2965
dc.identifier.pmcid PMC3709499
dc.identifier.pmid 23756381
dc.identifier.grantID 0832824 (National Science Foundation)
dc.identifier.grantID 0829805 (National Science Foundation)
dc.identifier.grantID 0728703 (National Science Foundation)
dc.identifier.grantID Howard Hughes Medical Institute postdoctoral fellowship (Life Sciences Research Foundation)
dc.identifier.grantID 1K99EB015331 (National Institutes of Health)
dc.type.publication publisher version


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