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    Integrating DNA strand-displacement circuitry with DNA tile self-assembly

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    Author
    Zhang, David Yu; Hariadi, Rizal F.; Choi, Harry M.T.; Winfree, Erik
    Date
    2013
    Abstract
    DNA nanotechnology has emerged as a reliable and programmable way of controlling matter at the nanoscale through the specificity of Watson–Crick base pairing, allowing both complex self-assembled structures with nanometer precision and complex reaction networks implementing digital and analog behaviors. Here we show how two well-developed frameworks, DNA tile self-assembly and DNA strand-displacement circuits, can be systematically integrated to provide programmable kinetic control of self-assembly. We demonstrate the triggered and catalytic isothermal self-assembly of DNA nanotubes over 10 μm long from precursor DNA double-crossover tiles activated by an upstream DNA catalyst network. Integrating more sophisticated control circuits and tile systems could enable precise spatial and temporal organization of dynamic molecular structures.
    Citation
    Zhang, David Yu, Hariadi, Rizal F., Choi, Harry M.T., et al.. "Integrating DNA strand-displacement circuitry with DNA tile self-assembly." Nature Communications, 4, (2013) Macmillan Publishers Limited: http://dx.doi.org/10.1038/ncomms2965.
    Published Version
    http://dx.doi.org/10.1038/ncomms2965
    Type
    Journal article
    Publisher
    Macmillan Publishers Limited
    Citable link to this page
    https://hdl.handle.net/1911/88317
    Rights
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
    Link to License
    http://creativecommons.org/licenses/by-nc-nd/3.0/
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    • Bioengineering Publications [677]
    • Faculty Publications [5397]

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    Home | FAQ | Contact Us | Privacy Notice | Accessibility Statement
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
    Site Map