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dc.contributor.authorLukianova-Hleb, Ekaterina Y.
Ren, Xiaoyang
Constantinou, Pamela E.
Danysh, Brian P.
Shenefelt, Derek L.
Carson, Daniel D.
Farach-Carson, Mary C.
Kulchitsky, Vladimir A.
Wu, Xiangwei
Wagner, Daniel S.
Lapotko, Dmitri O.
dc.date.accessioned 2016-02-01T17:23:58Z
dc.date.available 2016-02-01T17:23:58Z
dc.date.issued 2012
dc.identifier.citation Lukianova-Hleb, Ekaterina Y., Ren, Xiaoyang, Constantinou, Pamela E., et al.. "Improved Cellular Specificity of Plasmonic Nanobubbles versus Nanoparticles in Heterogeneous Cell Systems." PLoS ONE, 7, no. 4 (2012) Public Library of Science: e34537. http://dx.doi.org/10.1371/journal.pone.0034537.
dc.identifier.urihttps://hdl.handle.net/1911/88297
dc.description.abstract The limited specificity of nanoparticle (NP) uptake by target cells associated with a disease is one of the principal challenges of nanomedicine. Using the threshold mechanism of plasmonic nanobubble (PNB) generation and enhanced accumulation and clustering of gold nanoparticles in target cells, we increased the specificity of PNB generation and detection in target versus non-target cells by more than one order of magnitude compared to the specificity of NP uptake by the same cells. This improved cellular specificity of PNBs was demonstrated in six different cell models representing diverse molecular targets such as epidermal growth factor receptor, CD3 receptor, prostate specific membrane antigen and mucin molecule MUC1. Thus PNBs may be a universal method and nano-agent that overcome the problem of non-specific uptake of NPs by non-target cells and improve the specificity of NP-based diagnostics, therapeutics and theranostics at the cell level.
dc.language.iso eng
dc.publisher Public Library of Science
dc.rights This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.title Improved Cellular Specificity of Plasmonic Nanobubbles versus Nanoparticles in Heterogeneous Cell Systems
dc.type Journal article
dc.contributor.funder National Institutes of Health
dc.contributor.funder MD Anderson Gynecologic Specialized Programs of Research Excellence (SPORE) in Uterine Cancer, Pilot Project
dc.citation.journalTitle PLoS ONE
dc.citation.volumeNumber 7
dc.citation.issueNumber 4
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0034537
dc.identifier.pmcid PMC3317980
dc.identifier.pmid 22509318
dc.identifier.grantID R01GM094816 (National Institutes of Health)
dc.identifier.grantID P01 CA098912 (National Institutes of Health)
dc.identifier.grantID 2P50CA098258-06 (MD Anderson Gynecologic Specialized Programs of Research Excellence (SPORE) in Uterine Cancer, Pilot Project)
dc.identifier.grantID S10RR026399 01 (National Institutes of Health)
dc.type.publication publisher version
dc.citation.firstpage e34537


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