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dc.contributor.authorArner, Erik
Forrest, Alistair R.R.
Ehrlund, Anna
Mejhert, Niklas
Itoh, Masayoshi
Kawaji, Hideya
Lassmann, Timo
Laurencikiene, Jurga
Rydén, Mikael
Arner, Peter
FANTOM consortium
dc.date.accessioned 2016-02-01T17:23:58Z
dc.date.available 2016-02-01T17:23:58Z
dc.date.issued 2014
dc.identifier.citation Arner, Erik, Forrest, Alistair R.R., Ehrlund, Anna, et al.. "Ceruloplasmin Is a Novel Adipokine Which Is Overexpressed in Adipose Tissue of Obese Subjects and in Obesity-Associated Cancer Cells." PLoS ONE, 9, no. 3 (2014) Public Library of Science: e80274. http://dx.doi.org/10.1371/journal.pone.0080274.
dc.identifier.urihttps://hdl.handle.net/1911/88296
dc.description.abstract Obesity confers an increased risk of developing specific cancer forms. Although the mechanisms are unclear, increased fat cell secretion of specific proteins (adipokines) may promote/facilitate development of malignant tumors in obesity via cross-talk between adipose tissue(s) and the tissues prone to develop cancer among obese. We searched for novel adipokines that were overexpressed in adipose tissue of obese subjects as well as in tumor cells derived from cancers commonly associated with obesity. For this purpose expression data from human adipose tissue of obese and non-obese as well as from a large panel of human cancer cell lines and corresponding primary cells and tissues were explored. We found expression of ceruloplasmin to be the most enriched in obesity-associated cancer cells. This gene was also significantly up-regulated in adipose tissue of obese subjects. Ceruloplasmin is the body's main copper carrier and is involved in angiogenesis. We demonstrate that ceruloplasmin is a novel adipokine, which is produced and secreted at increased rates in obesity. In the obese state, adipose tissue contributed markedly (up to 22%) to the total circulating protein level. In summary, we have through bioinformatic screening identified ceruloplasmin as a novel adipokine with increased expression in adipose tissue of obese subjects as well as in cells from obesity-associated cancers. Whether there is a causal relationship between adipose overexpression of ceruloplasmin and cancer development in obesity cannot be answered by these cross-sectional comparisons.
dc.language.iso eng
dc.publisher Public Library of Science
dc.rights This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.title Ceruloplasmin Is a Novel Adipokine Which Is Overexpressed in Adipose Tissue of Obese Subjects and in Obesity-Associated Cancer Cells
dc.type Journal article
dc.citation.journalTitle PLoS ONE
dc.citation.volumeNumber 9
dc.citation.issueNumber 3
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0080274
dc.identifier.pmcid PMC3968011
dc.identifier.pmid 24676332
dc.type.publication publisher version
dc.citation.firstpage e80274


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