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dc.contributor.authorRadmaneshfar, Elahe
Kaloriti, Despoina
Gustin, Michael C.
Gow, Neil A.R.
Brown, Alistair J.P.
Grebogi, Celso
Romano, M. Carmen
Thiel, Marco
dc.date.accessioned 2016-01-29T22:36:34Z
dc.date.available 2016-01-29T22:36:34Z
dc.date.issued 2013
dc.identifier.citation Radmaneshfar, Elahe, Kaloriti, Despoina, Gustin, Michael C., et al.. "From START to FINISH: The Influence of Osmotic Stress on the Cell Cycle." PLoS ONE, 8, no. 7 (2013) Public Library of Science: e68067. http://dx.doi.org/10.1371/journal.pone.0068067.
dc.identifier.urihttps://hdl.handle.net/1911/88290
dc.description.abstract The cell cycle is a sequence of biochemical events that are controlled by complex but robust molecular machinery. This enables cells to achieve accurate self-reproduction under a broad range of different conditions. Environmental changes are transmitted by molecular signalling networks, which coordinate their action with the cell cycle. The cell cycle process and its responses to environmental stresses arise from intertwined nonlinear interactions among large numbers of simpler components. Yet, understanding of how these pieces fit together into a coherent whole requires a systems biology approach. Here, we present a novel mathematical model that describes the influence of osmotic stress on the entire cell cycle ofᅠS. cerevisiaefor the first time. Our model incorporates all recently known and several proposed interactions between the osmotic stress response pathway and the cell cycle. This model unveils the mechanisms that emerge as a consequence of the interaction between the cell cycle and stress response networks. Furthermore, it characterises the role of individual components. Moreover, it predicts different phenotypical responses for cells depending on the phase of cells at the onset of the stress. The key predictions of the model are: (i) exposure of cells to osmotic stress during the late S and the early G2/M phase can induce DNA re-replication before cell division occurs, (ii) cells stressed at the late G2/M phase display accelerated exit from mitosis and arrest in the next cell cycle, (iii) osmotic stress delays the G1-to-S and G2-to-M transitions in a dose dependent manner, whereas it accelerates the M-to-G1 transition independently of the stress dose and (iv) the Hog MAPK network compensates the role of the MEN network during cell division of MEN mutant cells. These model predictions are supported by independent experiments inᅠS. cerevisiaeᅠand, moreover, have recently been observed in other eukaryotes.
dc.language.iso eng
dc.publisher Public Library of Science
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/us/
dc.title From START to FINISH: The Influence of Osmotic Stress on the Cell Cycle
dc.type Journal article
dc.citation.journalTitle PLoS ONE
dc.citation.volumeNumber 8
dc.citation.issueNumber 7
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0068067
dc.identifier.pmcid PMC3707922
dc.identifier.pmid 23874495
dc.type.publication publisher version
dc.citation.firstpage e68067


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