Size-dependent impacts of silver nanoparticles on the lifespan, fertility, growth, and locomotion of Caenorhabditis elegans
Author
Contreras, Elizabeth Q.; Puppala, Hema L.; Escalera, Gabriela; Zhong, Weiwei; Colvin, Vicki L.
Date
2014Abstract
The increased bioavailability of nanoparticles engineered for good dispersion in water may have biological and environmental impacts. To examine this issue, the authors assessed the biological effects in nematodes as they relate to exposure to silver nanoparticles (AgNPs) of different sizes at low (1 mg/L Ag), medium (10 mg/L Ag), and high concentrations (100 mg/L Ag). Over multiple generations, the authors found that the smallest particle, at 2 nm, had a notable impact on nematode fertility. In contrast, the largest particle, at 10 nm, significantly reduced the lifespan of parent nematodes (P0) by 28.8% and over the span of 3 generations (F1–F3). In addition, a computer vision system automatically measured the adverse effects in body length and motility, which were not size-dependent.
Citation
Published Version
Keyword
Caenorhabditis elegans; silver nanoparticle; multigenerational; toxicity; Escherichia coli
Type
Journal article
Publisher
Citable link to this page
https://hdl.handle.net/1911/87883Rights
This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wiley.Metadata
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