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dc.contributor.authorYou, Ran
Lu, Wen
Shan, Ming
Berlin, Jacob M.
Samuel, Errol L.G.
Marcano, Daniela C.
Sun, Zhengzong
Sikkema, William K.A.
Yuan, Xiaoyi
Song, Lizhen
Hendrix, Amanda Y.
Tour, James M.
Corry, David B.
Kheradmand, Farrah
dc.date.accessioned 2016-01-15T19:47:52Z
dc.date.available 2016-01-15T19:47:52Z
dc.date.issued 2015
dc.identifier.citation You, Ran, Lu, Wen, Shan, Ming, et al.. "Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema." eLife, 4, (2015) e09623. http://dx.doi.org/10.7554/eLife.09623.
dc.identifier.urihttp://hdl.handle.net/1911/87856
dc.description.abstract Chronic inhalation of cigarette smoke is the major cause of sterile inflammation and pulmonary emphysema. The effect of carbon black (CB), a universal constituent of smoke derived from the incomplete combustion of organic material, in smokers and non-smokers is less known. In this study, we show that insoluble nanoparticulate carbon black (nCB) accumulates in human myeloid dendritic cells (mDCs) from emphysematous lung and in CD11c+ lung antigen presenting cells (APC) of mice exposed to smoke. Likewise, nCB intranasal administration induced emphysema in mouse lungs. Delivered by smoking or intranasally, nCB persisted indefinitely in mouse lung, activated lung APCs, and promoted T helper 17 cell differentiation through double-stranded DNA break (DSB) and ASC-mediated inflammasome assembly in phagocytes. Increasing the polarity or size of CB mitigated many adverse effects. Thus, nCB causes sterile inflammation, DSB, and emphysema and explains adverse health outcomes seen in smokers while implicating the dangers of nCB exposure in non-smokers.
dc.language.iso eng
dc.rights This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.title Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema
dc.type Journal article
dc.contributor.funder National Institutes of Health
dc.citation.journalTitle eLife
dc.citation.volumeNumber 4
dc.contributor.publisher eLife Sciences Publications Ltd.
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.7554/eLife.09623
dc.identifier.grantID NIAID P30AI036211 (National Institutes of Health)
dc.identifier.grantID NCI P30CA125123 (National Institutes of Health)
dc.identifier.grantID NCRR S10RR024574 (National Institutes of Health)
dc.identifier.grantID 1081701321-P30-CA (National Institutes of Health)
dc.identifier.grantID 1081701233-DLDCC (National Institutes of Health)
dc.identifier.grantID 1081701347-U54-HD (National Institutes of Health)
dc.identifier.grantID 1081701347-P30-DK (National Institutes of Health)
dc.type.publication publisher version
dc.citation.firstpage e09623


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This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Except where otherwise noted, this item's license is described as This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.