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dc.contributor.authorMcLaughlin, R. Tyler
Diehl, Michael R.
Kolomeisky, Anatoly B.
dc.date.accessioned 2016-01-14T20:01:03Z
dc.date.available 2016-01-14T20:01:03Z
dc.date.issued 2016
dc.identifier.citation McLaughlin, R. Tyler, Diehl, Michael R. and Kolomeisky, Anatoly B.. "Collective dynamics of processive cytoskeletal motors." Soft Matter, 12, (2016) Royal Society of Chemistry: 14-21. http://dx.doi.org/10.1039/C5SM01609F.
dc.identifier.urihttps://hdl.handle.net/1911/87818
dc.description.abstract Major cellular processes are supported by various biomolecular motors that usually operate together as teams. We present an overview of the collective dynamics of processive cytokeletal motor proteins based on recent experimental and theoretical investigations. Experimental studies show that multiple motors function with different degrees of cooperativity, ranging from negative to positive. This effect depends on the mechanical properties of individual motors, the geometry of their connections, and the surrounding cellular environment. Theoretical models based on stochastic approaches underline the importance of intermolecular interactions, the properties of single motors, and couplings with cellular medium in predicting the collective dynamics. We discuss several features that specify the cooperativity in motor proteins. Based on this approach a general picture of collective dynamics of motor proteins is formulated, and the future directions and challenges are discussed.
dc.language.iso eng
dc.publisher Royal Society of Chemistry
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the Royal Society of Chemistry.
dc.title Collective dynamics of processive cytoskeletal motors
dc.type Journal article
dc.contributor.funder Welch Foundation
dc.contributor.funder National Science Foundation
dc.contributor.funder National Institutes of Health
dc.citation.journalTitle Soft Matter
dc.contributor.org Center for Theoretical Biological Physics
dc.citation.volumeNumber 12
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1039/C5SM01609F
dc.identifier.grantID C-1559 (Welch Foundation)
dc.identifier.grantID CHE-1360979 (National Science Foundation)
dc.identifier.grantID GM094489-01 (National Institutes of Health)
dc.identifier.grantID PHY-142765 (National Science Foundation)
dc.identifier.grantID C-1625 (Welch Foundation)
dc.identifier.grantID GM094489-01 (National Institutes of Health)
dc.type.publication post-print
dc.citation.firstpage 14
dc.citation.lastpage 21


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