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dc.contributor.advisor Wilson, Lon J.
dc.creatorLaw, Justin Jonathan
dc.date.accessioned 2016-01-11T16:56:39Z
dc.date.available 2016-01-11T16:56:39Z
dc.date.created 2015-05
dc.date.issued 2015-04-21
dc.date.submitted May 2015
dc.identifier.citation Law, Justin Jonathan. "Ultrashort Single-walled Carbon Nanotubes: A Platform for Medical Imaging and Therapy." (2015) Diss., Rice University. https://hdl.handle.net/1911/87806.
dc.identifier.urihttps://hdl.handle.net/1911/87806
dc.description.abstract Ultra-short single-walled carbon nanotubes (US-tubes) have been used to encapsulate various metal ions and small molecules for both diagnostic and therapeutic applications. Of the US-tube derivatives, one of the best characterized is the gadonanotube (GNT). GNTs are remarkable due to their greatly enhanced relaxivity, which is up to 40 times larger than current clinically available gadolinium based contrast. The work in this thesis explores the mechanisms contributing to this phenomenon. This is accomplished by using a series of closely related chelating ligands to explore the role of the coordination environment on the loading, retention, and relaxivity of gadolinium ions within the US-tubes. Further, the chelation system is applied to the positron emitting radioisotope <sup>64</sup>Cu and concurrent loading with gadolinium ions to produce bimodal imaging agents is discussed. In order to assess the viability of US-tubes as a platform for delivering medically relevant molecules, the biocompatibility of the US-tubes is explored. The cellular uptake and subcellular localization of the US-tubes is determined by Raman mapping and differences in US-tube aggregation and cellular response are analyzed. A strategy for enhancing water solubility of US-tube derivatives while retaining encapsulated ions is discussed. Finally, the heating properties of US-tubes in an external radiofrequency field are assessed to determine potential therapeutic applications.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.subjectCarbon Nanotubes
Magnetic Resonance Imaging
Positron Emission Tomography
Radiofrequency Heating
dc.title Ultrashort Single-walled Carbon Nanotubes: A Platform for Medical Imaging and Therapy
dc.contributor.committeeMember Tour, James M
dc.contributor.committeeMember Wong, Michael S
dc.contributor.committeeMember Curley, Steven A
dc.date.updated 2016-01-11T16:56:39Z
dc.type.genre Thesis
dc.type.material Text
thesis.degree.department Chemistry
thesis.degree.discipline Natural Sciences
thesis.degree.grantor Rice University
thesis.degree.level Doctoral
thesis.degree.name Doctor of Philosophy


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