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dc.contributor.authorShin, Dongsuk
Lee, Michelle H.
Polydorides, Alexandros D.
Pierce, Mark C.
Vila, Peter M.
Parikh, Neil D.
Rosen, Daniel G.
Anandasabapathy, Sharmila
Richards-Kortum, Rebecca R.
dc.date.accessioned 2015-12-18T20:10:19Z
dc.date.available 2015-12-18T20:10:19Z
dc.date.issued 2016
dc.identifier.citation Shin, Dongsuk, Lee, Michelle H., Polydorides, Alexandros D., et al.. "Quantitative analysis of high-resolution microendoscopic images for diagnosis of neoplasia in patients with Barrett’s esophagus." Gastrointestinal Endoscopy, 83, no. 1 (2016) Elsevier: 107-114. http://dx.doi.org/10.1016/j.gie.2015.06.045.
dc.identifier.urihttps://hdl.handle.net/1911/87477
dc.description.abstract Background and Aims: Previous studies show that microendoscopic images can be interpreted visually to identify the presence of neoplasia in patients with Barrett’s esophagus (BE), but this approach is subjective and requires clinical expertise. This study describes an approach for quantitative image analysis of microendoscopic images to identify neoplastic lesions in patients with BE. Methods: Images were acquired from 230 sites from 58 patients by using a fiberoptic high-resolution microendoscope during standard endoscopic procedures. Images were analyzed by a fully automated image processing algorithm, which automatically selected a region of interest and calculated quantitative image features. Image features were used to develop an algorithm to identify the presence of neoplasia; results were compared with a histopathology diagnosis. Results: A sequential classification algorithm that used image features related to glandular and cellular morphology resulted in a sensitivity of 84% and a specificity of 85%. Applying the algorithm to an independent validation set resulted in a sensitivity of 88% and a specificity of 85%. Conclusions: This pilot study demonstrates that automated analysis of microendoscopic images can provide an objective, quantitative framework to assist clinicians in evaluating esophageal lesions from patients with BE. (Clinical trial registration number: NCT01384227 and NCT02018367.)
dc.language.iso eng
dc.publisher Elsevier
dc.rights This is an open access article under the CC BY-NC-ND license.
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Quantitative analysis of high-resolution microendoscopic images for diagnosis of neoplasia in patients with Barrett’s esophagus
dc.type Journal article
dc.contributor.funder National Cancer Institute, National Institutes of Health
dc.contributor.funder National Institute of Biomedical Imaging and Bioengineering
dc.citation.journalTitle Gastrointestinal Endoscopy
dc.citation.volumeNumber 83
dc.citation.issueNumber 1
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1016/j.gie.2015.06.045
dc.identifier.pmid 26253018
dc.identifier.grantID R01CA140257 (National Cancer Institute, National Institutes of Health)
dc.identifier.grantID R01EB007594 (National Institute of Biomedical Imaging and Bioengineering)
dc.type.publication publisher version
dc.citation.firstpage 107
dc.citation.lastpage 114


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