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dc.creatorAmbrose, Catherine G.
Clyburn, Terry A.
Mikos, Antonio G.
dc.date.accessioned 2015-12-18T17:47:04Z
dc.date.available 2015-12-18T17:47:04Z
dc.date.issued 2015-03-24
dc.identifier.citation Ambrose, Catherine G., Clyburn, Terry A. and Mikos, Antonio G., "Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth." Patent US8986737B2. issued 2015-03-24. Retrieved from https://hdl.handle.net/1911/87472.
dc.identifier.urihttps://hdl.handle.net/1911/87472
dc.description.abstract A method of treating or preventing infection at a surgical site comprising a bony defect and an implanted metal device is disclosed. Biodegradable microspheres are placed at the site and are capable of near-linear controlled release of an antibiotic agent for a predetermined period of time. The microspheres are configured to be large enough to avoid being phagocytosed and removed from the body, and small enough in diameter to not physically inhibit bone growth at said bony defect site. The microspheres are formed of polylactic-co-glycolic acid (PLGA), with or without polyethylene glycol (PEG), and sufficient antibiotic agent to produce bactericidal levels in body tissues. The microspheres exhibit near-linear delivery of the antibiotic agent for at least 4 weeks at levels exceeding the minimum inhibitory concentration (MIC) for organisms commonly found to be the cause of infections, and facilitate bone ingrowth or regrowth at the site.
dc.format.extent 17 pp
dc.language.iso eng
dc.title Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth
dc.type Utility patent
dc.digitization.specificationsThis patent information was downloaded from the US Patent and Trademark website (http://www.uspto.gov/) as image-PDFs. The PDFs were OCRed for access purposes
dc.contributor.publisher United States Patent and Trademark Office
dc.type.genre patents
dc.type.dcmi Text
dc.date.filed 2008-12-10
dc.identifier.patentID US8986737B2
dc.contributor.assignee Rice University


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