Rice Univesrity Logo
    • FAQ
    • Deposit your work
    • Login
    View Item 
    •   Rice Scholarship Home
    • Faculty & Staff Research
    • Faculty Publications
    • View Item
    •   Rice Scholarship Home
    • Faculty & Staff Research
    • Faculty Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Deformable complex network for refining low-resolution X-ray structures

    Thumbnail
    Name:
    dz5384.pdf
    Size:
    1.381Mb
    Format:
    PDF
    View/Open
    Author
    Zhang, Chong; Wang, Qinghua; Ma, Jianpeng
    Date
    2015
    Abstract
    In macromolecular X-ray crystallography, building more accurate atomic models based on lower resolution experimental diffraction data remains a great challenge. Previous studies have used a deformable elastic network (DEN) model to aid in low-resolution structural refinement. In this study, the development of a new refinement algorithm called the deformable complex network (DCN) is reported that combines a novel angular network-based restraint with the DEN model in the target function. Testing of DCN on a wide range of low-resolution structures demonstrated that it constantly leads to significantly improved structural models as judged by multiple refinement criteria, thus representing a new effective refinement tool for low-resolution structural determination.
    Citation
    Zhang, Chong, Wang, Qinghua and Ma, Jianpeng. "Deformable complex network for refining low-resolution X-ray structures." Acta Crystallographica, D71, (2015) International Union of Crystallography: 2150-2157. http://dx.doi.org/10.1107/S139900471501528X.
    Published Version
    http://dx.doi.org/10.1107/S139900471501528X
    Keyword
    deformable complex network; low-resolution X-ray refinement; homology modeling
    Type
    Journal article
    Publisher
    International Union of Crystallography
    Citable link to this page
    https://hdl.handle.net/1911/87463
    Rights
    This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
    Link to License
    http://creativecommons.org/licenses/by/4.0/
    Metadata
    Show full item record
    Collections
    • Bioengineering Publications [684]
    • Faculty Publications [5504]

    Home | FAQ | Contact Us | Privacy Notice | Accessibility Statement
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
    Site Map

     

    Searching scope

    Browse

    Entire ArchiveCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsTypeThis CollectionBy Issue DateAuthorsTitlesSubjectsType

    My Account

    Login

    Statistics

    View Usage Statistics

    Home | FAQ | Contact Us | Privacy Notice | Accessibility Statement
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
    Site Map