Now showing items 39-46 of 46

    • SIMS: A Hybrid Method for Rapid Conformational Analysis 

      Gipson, Bryant; Moll, Mark; Kavraki, Lydia E. (2013)
      Proteins are at the root of many biological functions, often performing complex tasks as the result of large changes in their structure. Describing the exact details of these conformational changes, however, remains a ...
    • Solving Partial-Information Stochastic Parity Games 

      Nain, Sumit; Vardi, Moshe Y. (2013)
      We study one-sided partial-information 2-player concurrent stochastic games with parity objectives. In such a game, one of the players has only partial visibility of the state of the game, while the other player has complete ...
    • Structure-guided selection of specificity determining positions in the human Kinome 

      Moll, Mark; Finn, Paul W; Kavraki, Lydia E (2016-08-18)
      Abstract Background The human kinome contains many important drug targets. It is well-known that inhibitors of protein kinases bind with very different selectivity profiles. ...
    • Synthesis from Probabilistic Components 

      Nain, Sumit; Lustig, Yoad; Vardi, Moshe Y. (2014)
      Synthesis is the automatic construction of a system from its specification. In classical synthesis algorithms, it is always assumed that the system is "constructed from scratch" rather than composed from reusable components. ...
    • Terahertz and Infrared Spectroscopy of Gated Large-Area Graphene 

      Ren, Lei; Zhang, Qi; Yao, Jun; Sun, Zhengzong; Kaneko, Ryosuke; Yan, Zheng; Nanot, Sébastien L.; Jin, Zhong; Kawayama, Iwao; Tonouchi, Masayoshi; Tour, James M.; Kono, Junichiro (2012)
      We have fabricated a centimeter-size single-layer graphene device with a gate electrode, which can modulate the transmission of terahertz and infrared waves. Using time-domain terahertz spectroscopy and Fourier-transform ...
    • Towards accurate characterization of clonal heterogeneity based on structural variation 

      Fan, Xian; Zhou, Wanding; Chong, Zechen; Nakhleh, Luay; Chen, Ken (2014)
      Recent advances in deep digital sequencing have unveiled an unprecedented degree of clonal heterogeneity within a single tumor DNA sample. Resolving such heterogeneity depends on accurate estimation of fractions of alleles ...
    • Transaction local aliasing in storage class memory 

      Giles, Ellis; Doshi, Kshitij; Varman, Peter (2015)
      This paper describes a lightweight software library to solve the challenges [6], [3], [1], [5], [2] of programming storage class memory (SCM). It provides primitives to demarcate failure-atomic code regions. SCM loads and ...
    • Understanding the challenges of protein flexibility in drug design 

      Antunes, Dinler A.; Devaurs, Didier; Kavraki, Lydia E. (2015)
      Introduction: Protein–ligand interactions play key roles in various metabolic pathways, and the proteins involved in these interactions represent major targets for drug discovery. Molecular docking is widely used to predict ...