Computational and Applied Mathematics
Recent Submissions

Predicting solvation free energies and thermodynamics in polar solvents and mixtures using a solvationlayer interface condition
(2017)We demonstrate that with two small modifications, the popular dielectric continuum model is capable of predicting, with high accuracy, ion solvation thermodynamics (Gibbs free energies, entropies, and heat capacities) in ... 
Modulation of Orthographic Decoding by Frontal Cortex
(2016)Opinions are divided on whether word reading processes occur in a hierarchical, feedforward fashion or within an interactive framework. To critically evaluate these competing theories, we recorded electrocorticographic ... 
A Topological Model of the Hippocampal Cell Assembly Network
(2016)It is widely accepted that the hippocampal place cells' spiking activity produces a cognitive map of space. However, many details of this representation's physiological mechanism remain unknown. For example, it is believed ... 
Levetiracetam mitigates doxorubicininduced DNA and synaptic damage in neurons
(2016)Neurotoxicity may occur in cancer patients and survivors during or after chemotherapy. Cognitive deficits associated with neurotoxicity can be subtle or disabling and frequently include disturbances in memory, attention, ... 
Topological Schemas of Cognitive Maps and Spatial Learning
(2016)Spatial navigation in mammals is based on building a mental representation of their environmenta cognitive map. However, both the nature of this cognitive map and its underpinning in neural structures and activity remains ... 
The MinimalﾠkCore Problem for Modelingﾠ kAssemblies
(2015)The concept of cell assembly was introduced by Hebb and formalized mathematically by Palm in the framework of graph theory. In the study of associative memory, a cell assembly is a group of neurons that are strongly connected ... 
Cytoplasmic sphingosine1phosphate pathway modulates neuronal autophagy
(2015)Autophagy is an important homeostatic mechanism that eliminates longlived proteins, protein aggregates and damaged organelles. Its dysregulation is involved in many neurodegenerative disorders. Autophagy is therefore a ... 
A MatrixFree TrustRegion SQP Method for Equality Constrained Optimization
(2014)We develop and analyze a trustregion sequential quadratic programming (SQP) method for the solution of smooth equality constrained optimization problems, which allows the inexact and hence iterative solution of linear ... 
Convergence of a high order method in time and space for the miscible displacement equations
(2015)A numerical method is formulated and analyzed for solving the miscible displacement problem under low regularity assumptions. The scheme employs discontinuous Galerkin time stepping with mixed and interior penalty discontinuous ... 
Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer's Disease
(2014)Alzheimer's disease (AD) is associated with an elevated risk for seizures that may be fundamentally connected to cognitive dysfunction. Supporting this link, many mouse models for AD exhibit abnormal electroencephalogram ... 
Limited Memory Block Krylov Subspace Optimization for Computing Dominant Singular Value Decompositions
(2013)In many dataintensive applications, the use of principal component analysis and other related techniques is ubiquitous for dimension reduction, data mining, or other transformational purposes. Such transformations often ... 
A Posteriori Error Estimation for DEIM Reduced Nonlinear Dynamical Systems
(2014)In this work an efficient approach for a posteriori error estimation for PODDEIM reduced nonlinear dynamical systems is introduced. The considered nonlinear systems may also include time and parameteraffine linear terms ... 
A TrustRegion Algorithm with Adaptive Stochastic Collocation for PDE Optimization under Uncertainty
(2013)The numerical solution of optimization problems governed by partial differential equations (PDEs) with random coefficients is computationally challenging because of the large number of deterministic PDE solves required at ... 
A mathematical framework for inverse wave problems in heterogeneous media
(2013)This paper provides a theoretical foundation for some common formulations of inverse problems in wave propagation, based on hyperbolic systems of linear integrodifferential equations with bounded and measurable coefficients. ... 
Horizontal contraction in image domain for velocity inversion
(2015)A kinematically correct choice of velocity focuses subsurface offset image gathers at a zero offset. Infinitesimal warping from the current image toward its focus can be approximated by a horizontal contraction. The image ... 
Model reduction of strongweak neurons
(2014)We consider neurons with large dendritic trees that are weakly excitable in the sense that back propagating action potentials are severly attenuated as they travel from the small, strongly excitable, spike initiation zone. ... 
The Effects of Theta Precession on Spatial Learning and Simplicial Complex Dynamics in a Topological Model of the Hippocampal Spatial Map
(2014)Learning arises through the activity of large ensembles of cells, yet most of the data neuroscientists accumulate is at the level of individual neurons; we need models that can bridge this gap. We have taken spatial learning ... 
TimeDependent Coupling of NavierStokes and Darcy Flows
(2013)A weak solution of the coupling of timedependent incompressible NavierﾖStokes equations with Darcy equations is defined. The interface conditions include the BeaversﾖJosephﾖSaffman condition. Existence and uniqueness of ... 
An Algebraic Exploration of Dominating Sets and Vizing's Conjecture
(2012)Systems of polynomial equations are commonly used to model combinatorial problems such as independent set, graph coloring, Hamiltonian path, and others. We formulate the dominating set problem as a system of polynomial ... 
Ritz Value for NonHermitian Matrices
(2012)RayleighRitz eigenvalue estimates for Hermitian matrices obey Cauchy interlacing, which has helpful implications for theory, applications, and algorithms. In contrast, few results about the Ritz values of nonHermitian ...