Now showing items 1-6 of 6

    • Biocompatible Carbon Nanotube–Chitosan Scaffold Matching the Electrical Conductivity of the Heart 

      Pok, Seokwon; Vitale, Flavia; Eichmann, Shannon L.; Benavides, Omar M.; Pasquali, Matteo; Jacot, Jeffrey G. (2014)
      The major limitation of current engineered myocardial patches for the repair of heart defects is that insulating polymeric scaffold walls hinder the transfer of electrical signals between cardiomyocytes. This loss in signal ...
    • In vitroᅠandᅠin vivoᅠevaluation of self-mineralization and biocompatibility of injectable, dual-gelling hydrogels for bone tissue engineering 

      Vo, Tiffany N.; Ekenseair, Adam K.; Spicer, Patrick P.; Watson, Brendan M.; Tzouanas, Stephanie N.; Roh, Terrence T.; Mikos, Antonios G. (2015)
      In this study, we investigated the mineralization capacity and biocompatibility of injectable, dual-gelling hydrogels in a rat cranial defect as a function of hydrogel hydrophobicity from either the copolymerization of a ...
    • Leveraging synthetic biology for tissue engineering applications 

      Lee, Esther J.; Tabor, Jeffrey J.; Mikos, Antonios G. (2014)
      Restoration of damaged tissues and organs requires precise control of cellular processes at the molecular level. Synthetic biology offers genetic tools that can be used to program the molecular biology of the cell, thereby ...
    • Novel applications of statins for bone regeneration 

      Shah, Sarita R.; Werlang, Caroline A.; Kasper, F. Kurtis; Mikos, Antonios G. (2015)
      The use of statins for bone regeneration is a promising and growing area of research. Statins, originally developed to treat high cholesterol, are inhibitors of the enzyme 3-hydroxy-3-methylglutaryl, the rate-limiting ...
    • Synthesis of oligo(poly(ethylene glycol) fumarate) 

      Kinard, Lucas A.; Kasper, F. Kurtis; Mikos, Antonios G. (2012)
      This protocol describes the synthesis of oligo(poly(ethylene glycol) fumarate) (OPF) (1-35 kDa)(a polymer useful for tissue engineering applications) by a one-pot reaction of poly(ethylene glycol) (PEG) and fumaryl chloride. ...
    • Tissue engineering perfusable cancer models 

      Fong, E.L.; Santoro, M.; Farach-Carson, M.C.; Kasper, F.K.; Mikos, A.G. (2014)
      The effect of fluid flow on cancer progression is currently not well understood, highlighting the need for perfused tumor models to close this gap in knowledge. Enabling biological processes at the cellular level to be ...