Now showing items 1-20 of 645

    • Post-Acquisition Hyperpolarized 29Silicon Magnetic Resonance Image Processing for Visualization of Colorectal Lesions Using a User-Friendly Graphical Interface 

      McCowan, Caitlin V.; Salmon, Duncan; Hu, Jingzhe; Pudakalakatti, Shivanand; Whiting, Nicholas; (2022)
      Medical imaging devices often use automated processing that creates and displays a self-normalized image. When improperly executed, normalization can misrepresent information or result in an inaccurate analysis. In the case of diagnostic imaging, a false positive in the absence of disease, or a negative finding when disease is present, can produce a ...
    • Current progress and open challenges for applying deep learning across the biosciences 

      Sapoval, Nicolae; Aghazadeh, Amirali; Nute, Michael G.; Antunes, Dinler A.; Balaji, Advait; (2022)
      Deep Learning (DL) has recently enabled unprecedented advances in one of the grand challenges in computational biology: the half-century-old problem of protein structure prediction. In this paper we discuss recent advances, limitations, and future perspectives of DL on five broad areas: protein structure prediction, protein function prediction, genome ...
    • Evidence-based biomaterials research 

      Zhang, Kai; Ma, Bin; Hu, Kaiyan; Yuan, Bo; Sun, Xin; (2022)
      The fast development of biomaterials science and engineering has generated significant number of studies and publications as well as tremendous amount of research data. A methodology is needed to translate such research data and results to validated scientific evidence. This article for the first time proposes the concept and methodology of evidence-based ...
    • Significance of aortoseptal angle anomalies to left ventricular hemodynamics and subaortic stenosis: A numerical study 

      Shar, Jason A.; Keswani, Sundeep G.; Grande-Allen, K. Jane; Sucosky, Philippe (2022)
      Purpose Discrete subaortic stenosis (DSS) is an obstructive cardiac disease caused by a membranous lesion in the left ventricular (LV) outflow tract (LVOT). Although its etiology is unknown, the higher prevalence of DSS in LVOT anatomies featuring a steep aortoseptal angle (AoSA) suggests a potential role for hemodynamics. Therefore, the objective ...
    • Sample-to-answer, extraction-free, real-time RT-LAMP test for SARS-CoV-2 in nasopharyngeal, nasal, and saliva samples: Implications and use for surveillance testing 

      Kundrod, Kathryn A.; Natoli, Mary E.; Chang, Megan M.; Smith, Chelsey A.; Paul, Sai; (2022)
      The global COVID-19 pandemic has highlighted the need for rapid, accurate and accessible nucleic acid tests to enable timely identification of infected individuals. We optimized a sample-to-answer nucleic acid test for SARS-CoV-2 that provides results in <1 hour using inexpensive and readily available reagents. The test workflow includes a simple ...
    • Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 

      El-Shennawy, Lamiaa; Hoffmann, Andrew D.; Dashzeveg, Nurmaa Khund; McAndrews, Kathleen M.; Mehl, Paul J.; (2022)
      The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the pandemic of the coronavirus induced disease 2019 (COVID-19) with evolving variants of concern. It remains urgent to identify novel approaches against broad strains of SARS-CoV-2, which infect host cells via the entry receptor angiotensin-converting enzyme 2 (ACE2). Herein, ...
    • Hands-On Training Courses for Cervical Cancer Screening, Diagnosis, and Treatment Procedures in Low- and Middle-Income Countries 

      Phoolcharoen, Natacha; Varon, Melissa Lopez; Baker, Ellen; Parra, Sonia; Carns, Jennifer; (2022)
      In 2018, there were approximately 570,000 new cases of cervical cancer worldwide. More than 85% of cases occurred in low- and middle-income countries (LMICs), primarily because of poor access to screening and a limited number of medical providers trained to diagnose and treat cervical precancerous lesions. Our objective was to provide locally arranged, ...
    • Deep Learning for Automated Analysis of Cellular and Extracellular Components of the Foreign Body Response in Multiphoton Microscopy Images 

      Sarti, Mattia; Parlani, Maria; Diaz-Gomez, Luis; Mikos, Antonios G.; Cerveri, Pietro; (2022)
      The Foreign body response (FBR) is a major unresolved challenge that compromises medical implant integration and function by inflammation and fibrotic encapsulation. Mice implanted with polymeric scaffolds coupled to intravital non-linear multiphoton microscopy acquisition enable multiparametric, longitudinal investigation of the FBR evolution and ...
    • Nodal is a short-range morphogen with activity that spreads through a relay mechanism in human gastruloids 

      Liu, Lizhong; Nemashkalo, Anastasiia; Rezende, Luisa; Jung, Ji Yoon; Chhabra, Sapna; (2022)
      Morphogens are signaling molecules that convey positional information and dictate cell fates during development. Although ectopic expression in model organisms suggests that morphogen gradients form through diffusion, little is known about how morphogen gradients are created and interpreted during mammalian embryogenesis due to the combined difficulties ...
    • Bone-Specific Enhancement of Antibody Therapy for Breast Cancer Metastasis to Bone 

      Tian, Zeru; Yu, Chenfei; Zhang, Weijie; Wu, Kuan-Lin; Wang, Chenhang; (2022)
      Despite the rapid evolution of therapeutic antibodies, their clinical efficacy in the treatment of bone tumors is hampered due to the inadequate pharmacokinetics and poor bone tissue accessibility of these large macromolecules. Here, we show that engineering therapeutic antibodies with bone-homing peptide sequences dramatically enhances their ...
    • Stem cell–homing hydrogel-based miR-29b-5p delivery promotes cartilage regeneration by suppressing senescence in an osteoarthritis rat model 

      Zhu, Jinjin; Yang, Shuhui; Qi, Yadong; Gong, Zhe; Zhang, Haitao; (2022)
      Osteoarthritis (OA) is a common joint disease characterized by progressive loss of cartilage and reduction in lubricating synovial fluid, which lacks effective treatments currently. Here, we propose a hydrogel-based miRNA delivery strategy to rejuvenate impaired cartilage by creating a regenerative microenvironment to mitigate chondrocyte senescence ...
    • Ruggedized, field-ready snapshot light-guide-based imaging spectrometer for environmental and remote sensing applications 

      Flynn, Christopher; Stoian, Razvan I.; Weers, Brock D.; Mullet, John E.; Thomasson, J. Alex; (2022)
      A field-ready, fiber-based high spatial sampling snapshot imaging spectrometer was developed for applications such as environmental monitoring and smart farming. The system achieves video rate frame transfer and exposure times down to a few hundred microseconds in typical daylight conditions with ∼63,000 spatial points and 32 spectral channels across ...
    • Correlation of nuclear pIGF-1R/IGF-1R and YAP/TAZ in a tissue microarray with outcomes in osteosarcoma patients 

      Molina, Eric R.; Chim, Letitia K.; Lamhamedi-Cherradi, Salah-Eddine; Mohiuddin, Sana; McCall, David; (2022)
      Osteosarcoma (OS) is a genetically diverse bone cancer that lacks a consistent targetable mutation. Recent studies suggest the IGF/PI3K/mTOR pathway and YAP/TAZ paralogs regulate cell fate and proliferation in response to biomechanical cues within the tumor microenvironment. How this occurs and their implication upon osteosarcoma survival, remains ...
    • Strategies for Improving Small-Molecule Biosensors in Bacteria 

      Miller, Corwin A.; Ho, Joanne M. L.; Bennett, Matthew R. (2022)
      In recent years, small-molecule biosensors have become increasingly important in synthetic biology and biochemistry, with numerous new applications continuing to be developed throughout the field. For many biosensors, however, their utility is hindered by poor functionality. Here, we review the known types of mechanisms of biosensors within bacterial ...
    • Development of 3D Printed Mitral Valve Constructs for Transcatheter Device Modeling of Tissue and Device Deformation 

      Vukicevic, Marija; Mehta, Shail Maharshi; Grande-Allen, K. Jane; Little, Stephen H. (2022)
      Transcatheter mitral valve repair (TMVR) therapies offer a minimally invasive alternative to surgical mitral valve (MV) repair for patients with prohibitive surgical risks. Pre-procedural planning and associated medical device modeling is primarily performed in silico, which does not account for the physical interactions between the implanted TMVR ...
    • Translation of biomaterials from bench to clinic 

      Zhang, Kai; Mikos, Antonios G.; Reis, Rui L.; Zhang, Xingdong (2022)
      Scientific research originates from curiosity and interests. Translational research of biomaterials should always focus on addressing specific needs of the targeted clinical applications. The guest editors of this special issue hope that the included articles have provided cutting-edge biomaterials research as well as insights of the translation of ...
    • The energy cost and optimal design of networks for biological discrimination 

      Yu, Qiwei; Kolomeisky, Anatoly B.; Igoshin, Oleg A.; Center for Theoretical Biological Physics (2022)
      Many biological processes discriminate between correct and incorrect substrates through the kinetic proofreading mechanism that enables lower error at the cost of higher energy dissipation. Elucidating physico-chemical constraints for global minimization of dissipation and error is important for understanding enzyme evolution. Here, we identify ...
    • National scale of neonatal CPAP to district hospitals in Malawi improves survival for neonates weighing between 1.0 and 1.3 kg 

      Carns, Jennifer; Liaghati-Mobarhan, Sara; Asibon, Aba; Chalira, Alfred; Lufesi, Norman; (2022)
      Objective To determine whether a national quality improvement programme implementing continuous positive airway pressure (CPAP) at government hospitals in Malawi improved outcomes for neonates prioritised by an algorithm recommending early CPAP for infants weighing 1.0–1.3 kg (the 50th percentile weight at 30 weeks’ gestation). Design The analysis ...
    • Additive manufacturing for the development of optical/photonic systems and components 

      Berglund, Gregory; Wisniowiecki, Anna; Gawedzinski, John; Applegate, Brian; Tkaczyk, Tomasz S. (2022)
      The ambition of this review is to provide an up-to-date synopsis of the state of 3D printing technology for optical and photonic components, to gauge technological advances, and to discuss future opportunities. While a range of approaches have been developed and some have been commercialized, no single approach can yet simultaneously achieve small ...
    • A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves 

      Chen, Joshua C.; Kan, Peter; Yu, Zhanghao; Alrashdan, Fatima; Garcia, Roberto; (2022)
      Implantable bioelectronic devices for the simulation of peripheral nerves could be used to treat disorders that are resistant to traditional pharmacological therapies. However, for many nerve targets, this requires invasive surgeries and the implantation of bulky devices (about a few centimetres in at least one dimension). Here we report the design ...