Now showing items 291-310 of 358

    • Sequence Effects of Self-Assembling MultiDomain Peptide Hydrogels on Encapsulated SHED Cells 

      Kang, Marci K.; Colombo, John S.; D’Souza, Rena N.; Hartgerink, Jeffrey D. (2014)
      Here we report three new nanofibrous, self-assembling multidomain peptide (MDP) sequences and examine the effect of sequence on the morphology and expansion of encapsulated Stem cells from Human Exfoliated Deciduous teeth ...
    • A Shipping Container-Based Sterile Processing Unit for Low Resources Settings 

      Boubour, Jean; Jenson, Katherine; Richter, Hannah; Yarbrough, Josiah; Oden, Z. Maria; Schuler, Douglas A. (2016)
      Deficiencies in the sterile processing of medical instruments contribute to poor outcomes for patients, such as surgical site infections, longer hospital stays, and deaths. In low resources settings, such as some rural and ...
    • Simulation Predicts IGFBP2-HIF1α Interaction Drives Glioblastoma Growth 

      Lin, Ka Wai; Liao, Angela; Qutub, Amina A. (2015)
      Tremendous strides have been made in improving patients’ survival from cancer with one glaring exception: brain cancer. Glioblastoma is the most common, aggressive and highly malignant type of primary brain tumor. The ...
    • Simulation-guided DNA probe design for consistently ultraspecific hybridization 

      Wang, Juexiao Sherry; Zhang, David Yu (2015)
      Hybridization of complementary sequences is one of the central tenets of nucleic acid chemistry; however, the unintended binding of closely related sequences limits the accuracy of hybridization-based approaches to analysing ...
    • Single molecule force measurements of perlecan/HSPG2: A key component of the osteocyte pericellular matrix 

      Wijeratne, Sithara S.; Martinez, Jerahme R.; Grindel, Brian J.; Frey, Eric W.; Li, Jingqiang; Wang, Liyun; Farach-Carson, Mary C.; Kiang, Ching-Hwa (2016)
      Perlecan/HSPG2, a large, monomeric heparan sulfate proteoglycan (HSPG), is a key component of the lacunar canalicular system (LCS) of cortical bone, where it is part of the mechanosensing pericellular matrix (PCM) surrounding ...
    • Single molecule targeted sequencing for cancer gene mutation detection 

      Gao, Yan; Deng, Liwei; Yan, Qin; Gao, Yongqian; Wu, Zengding; Cai, Jinsen; Ji, Daorui; Li, Gailing; Wu, Ping; Jin, Huan; Zhao, Luyang; Liu, Song; Ge, Liangjin; Deem, Michael W.; He, Jiankui (2016)
      With the rapid decline in cost of sequencing, it is now affordable to examine multiple genes in a single disease-targeted clinical test using next generation sequencing. Current targeted sequencing methods require a separate ...
    • Single-molecule force measurements of the polymerizing dimeric subunit of von Willebrand factor 

      Wijeratne, Sithara S.; Li, Jingqiang; Yeh, Hui-Chun; Nolasco, Leticia; Zhou, Zhou; Bergeron, Angela; Frey, Eric W.; Moake, Joel L.; Dong, Jing-fei; Kiang, Ching-Hwa (2016)
      Von Willebrand factor (VWF) multimers are large adhesive proteins that are essential to the initiation of hemostatic plugs at sites of vascular injury. The binding of VWF multimers to platelets, as well as VWF proteolysis, ...
    • Slowdown of growth controls cellular differentiation 

      Narula, Jatin; Kuchina, Anna; Zhang, Fang; Fujita, Masaya; Süel, Gürol M.; Igoshin, Oleg A. (2016)
      How can changes in growth rate affect the regulatory networks behavior and the outcomes of cellular differentiation? We address this question by focusing on starvation response in sporulating Bacillus subtilis. We show ...
    • Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans 

      Osman, Narin; Grande-Allen, K. Jane; Ballinger, Mandy L.; Getachew, Robel; Marasco, Silvana; O'Brien, Kevin D.; Little, Peter J. (2013)
      Objective: Calcific aortic valve disease is a progressive condition that shares some common pathogenic features with atherosclerosis. Transforming growth factor-β1 is a recognized mediator of atherosclerosis and is expressed ...
    • Snapshot 3D optical coherence tomography system using image mapping spectrometry 

      Nguyen, Thuc-Uyen; Pierce, Mark C.; Higgins, Laura; Tkaczyk, Tomasz S. (2013)
      A snapshot 3-Dimensional Optical Coherence Tomography system was developed using Image Mapping Spectrometry. This system can give depth information (Z) at different spatial positions (XY) within one camera integration time ...
    • Snapshot advantage: a review of the light collection improvement for parallel high-dimensional measurement systems 

      Hagen, Nathan; Kester, Robert T.; Gao, Liang; Tkaczyk, Tomasz S. (2012)
      The snapshot advantage is a large increase in light collection efficiency available to highdimensional measurement systems that avoid filtering and scanning. After discussing this advantage in the context of imaging ...
    • Snapshot spectrally encoded fluorescence imaging through a fiber bundle 

      Bedard, Noah; Tkaczyk, Tomasz S. (2012)
      Fiber optic endomicroscopy is a valuable tool for clinical diagnostics and animal studies because it can capture images of tissue in vivo with subcellular resolution. Current configurations for endomicroscopes have ...
    • Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease 

      Jarrett, Kelsey E.; Lee, Ciaran M.; Yeh, Yi-Hsien; Hsu, Rachel H.; Gupta, Rajat; Zhang, Min; Rodriguez, Perla J.; Lee, Chang Seok; Gillard, Baiba K.; Bissig, Karl-Dimiter; Pownall, Henry J.; Martin, James F.; Bao, Gang; Lagor, William R. (2017)
      Germline manipulation using CRISPR/Cas9 genome editing has dramatically accelerated the generation of new mouse models. Nonetheless, many metabolic disease models still depend upon laborious germline targeting, and are ...
    • Sources of Variability in a Synthetic Gene Oscillator 

      Veliz-Cuba, Alan; Hirning, Andrew J.; Atanas, Adam A.; Hussain, Faiza; Vancia, Flavia; Josić, Krešimir; Bennett, Matthew R. (2015)
      Synthetic gene oscillators are small, engineered genetic circuits that produce periodic variations in target protein expression. Like other gene circuits, synthetic gene oscillators are noisy and exhibit fluctuations in ...
    • A spheroid toxicity assay using magnetic 3D bioprinting and real-time mobile device-based imaging 

      Tseng, Hubert; Gage, Jacob A.; Shen, Tsaiwei; Haisler, William L.; Neeley, Shane K.; Shiao, Sue; Chen, Jianbo; Desai, Pujan K.; Liao, Angela; Hebel, Chris; Raphael, Robert M.; Becker, Jeanne L.; Souza, Glauco R. (2015)
      An ongoing challenge in biomedical research is the search for simple, yet robust assays using 3D cell cultures for toxicity screening. This study addresses that challenge with a novel spheroid assay, wherein spheroids, ...
    • Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer 

      Jain, Shalini; Wang, Xiao; Chang, Chia-Chi; Ibarra-Drendall, Catherine; Wang, Hai; Zhang, Qingling; Brady, Samuel W.; Li, Ping; Zhao, Hong; Dobbs, Jessica; Kyrish, Matt; Tkaczyk, Tomasz S.; Ambrose, Adrian; Sistrunk, Christopher; Arun, Banu K.; Richards-Kortum, Rebecca; Jia, Wei; Seewaldt, Victoria L.; Yu, Dihua (2015)
      Preventing breast cancer will require the development of targeted strategies that can effectively block disease progression. Tamoxifen and aromatase inhibitors are effective in addressing estrogen receptor–positive (ER+) ...
    • Stability of bacterial toggle switches is enhanced by cell-cycle lengthening by several orders of magnitude 

      Jaruszewicz, Joanna; Kimmel, Marek; Lipniacki, Tomasz (2014)
      Bistable regulatory elements are important for nongenetic inheritance, increase of cell-to-cell heterogeneity allowing adaptation, and robust responses at the population level. Here, we study computationally the bistable ...
    • Stability of the hybrid epithelial/mesenchymal phenotype 

      Jolly, Mohit Kumar; Tripathi, Satyendra C.; Jia, Dongya; Mooney, Steven M.; Celiktas, Muge; Hanash, Samir M.; Mani, Sendurai A.; Pienta, Kenneth J.; Ben-Jacob, Eshel; Levine, Herbert (2016)
      Epithelial-to-Mesenchymal Transition (EMT) and its reverse - Mesenchymal to Epithelial Transition (MET) - are hallmarks of cellular plasticity during embryonic development and cancer metastasis. During EMT, epithelial cells ...
    • Stem Cells and Progenitor Cells for Tissue-Engineered Solutions to Congenital Heart Defects 

      Gao, Yang; Jacot, Jeffrey G. (2015)
      Synthetic patches and fixed grafts currently used in the repair of congenital heart defects are nonliving, noncontractile, and not electrically responsive, leading to increased risk of complication, reoperation, and sudden ...
    • Stochastic hypothesis of transition from inborn neutropenia to AML: interactions of cell population dynamics and population genetics 

      Kimmel, Marek; Corey, Seth (2013)
      We present a stochastic model of driver mutations in the transition from severe congenital neutropenia to myelodysplastic syndrome to acute myeloid leukemia (AML). The model has the form of a multitype branching process.We ...