Now showing items 328-347 of 358

    • T Cell Repertoire Diversity Is Decreased in Type 1 Diabetes Patients 

      Tong, Yin; Li, Zhoufang; Zhang, Hua; Xia, Ligang; Zhang, Meng; Xu, Ying; Wang, Zhanhui; Deem, Michael W.; Sun, Xiaojuan; He, Jiankui (2016)
      Type 1 diabetes mellitus (T1D) is an immune-mediated disease. The autoreactive T cells in T1D patients attack and destroy their own pancreatic cells. In order to systematically investigate the potential autoreactive T cell ...
    • Template–Framework Interactions in Tetraethylammonium-Directed Zeolite Synthesis 

      Schmidt, Joel E.; Fu, Donglong; Deem, Michael W.; Weckhuysen, Bert M. (2016)
      Zeolites, having widespread applications in chemical industries, are often synthesized using organic templates. These can be cost-prohibitive, motivating investigations into their role in promoting crystallization. Herein, ...
    • Terahertz and Infrared Spectroscopy of Gated Large-Area Graphene 

      Ren, Lei; Zhang, Qi; Yao, Jun; Sun, Zhengzong; Kaneko, Ryosuke; Yan, Zheng; Nanot, Sébastien L.; Jin, Zhong; Kawayama, Iwao; Tonouchi, Masayoshi; Tour, James M.; Kono, Junichiro (2012)
      We have fabricated a centimeter-size single-layer graphene device with a gate electrode, which can modulate the transmission of terahertz and infrared waves. Using time-domain terahertz spectroscopy and Fourier-transform ...
    • TFEB regulates lysosomal proteostasis 

      Song, Wensi; Wang, Fan; Savini, Marzia; Ake, Ashley; di Ronza, Alberto; Sardiello, Marco; Segatori, Laura (2013)
      Loss-of-function diseases are often caused by destabilizing mutations that lead to protein misfolding and degradation. Modulating the innate protein homeostasis (proteostasis) capacity may lead to rescue of native folding ...
    • TGF-β3-induced chondrogenesis in co-cultures of chondrocytes and mesenchymal stem cells on biodegradable scaffolds 

      Dahlin, Rebecca L.; Ni, Mengwei; Meretoja, Ville V.; Kasper, F. Kurtis; Mikos, Antonios G. (2014)
      In this work, it was hypothesized that co-cultures of articular chondrocytes (ACs) and mesenchymal stem cells (MSCs) would exhibit enhanced sensitivity to chondrogenic stimuli, such as TGF-β3, and would require a reduced ...
    • Three dimensional model for surgical planning in resection of thoracic tumors 

      Kim, Min P.; Ta, Anderson H.; Ellsworth, Warren A. IV; Marco, Rex A.; Gaur, Puja; Miller, Jordan S. (2015)
      INTRODUCTION: The computed tomography scan provides vital information about the relationship of thoracic malignancies to the surrounding structures and aids in surgical planning. However, it can be difficult to visualize ...
    • Three-dimensional (3D) culture of bone-derived human 786-O renal cell carcinoma retains relevant clinical characteristics of bone metastases 

      Pan, Tianhong; Fong, Eliza L.S.; Martinez, Mariane; Harrington, Daniel A.; Lin, Sue-Hwa; Farach-Carson, Mary C.; Satcher, Robert L. (2015)
      Bone metastases from renal cell carcinoma (RCC) are typically lytic, destructive, and resistant to treatment regimens. Current in vitro models for studying metastasis introduce artifacts that limit their usefulness. Many ...
    • Three-dimensional in vitro tumor models for cancer research and drug evaluation 

      Xu, Xian; Farach-Carson, Mary C.; Jia, Xinqiao (2014)
      Cancer occurs when cells acquire genomic instability and inflammation, produce abnormal levels of epigenetic factors/proteins and tumor suppressors, reprogram the energy metabolism and evade immune destruction, leading to ...
    • Three-dimensional photolithographic micropatterning: a novel tool to probe the complexities of cell migration 

      Hoffmann, Joseph C.; West, Jennifer L. (2013)
      In order to independently study the numerous variables that influence cell movement, it will be necessary to employ novel tools and materials that allow for exquisite control of the cellular microenvironment. In this work, ...
    • The three-way switch operation of Rac1/RhoA GTPase-based circuit controlling amoeboid-hybrid-mesenchymal transition 

      Huang, Bin; Lu, Mingyang; Jolly, Mohit Kumar; Tsarfaty, Ilan; Onuchic, José; Ben-Jacob, Eshel (2014)
      Metastatic carcinoma cells exhibit at least two different phenotypes of motility and invasion - amoeboid and mesenchymal. This plasticity poses a major clinical challenge for treating metastasis, while its underlying ...
    • Tissue Engineered, Hydrogel-Based Endothelial Progenitor Cell Therapy Robustly Revascularizes Ischemic Myocardium and Preserves Ventricular Function 

      Atluri, Pavan; Miller, Jordan S.; Emery, Robert J.; Hung, George; Trubelja, Alen; Cohen, Jeffrey E.; Lloyd, Kelsey; Han, Jason; Gaffey, Ann C.; MacArthur, John W.; Chen, Christopher S.; Woo, Y. Joseph (2014)
      Objectives: Cell-based angiogenic therapy for ischemic heart failure has had limited clinical impact, likely related to low cell retention (<1%) and dispersion. We developed a novel, tissue-engineered, hydrogel-based ...
    • Tissue engineering perfusable cancer models 

      Fong, E.L.; Santoro, M.; Farach-Carson, M.C.; Kasper, F.K.; Mikos, A.G. (2014)
      The effect of fluid flow on cancer progression is currently not well understood, highlighting the need for perfused tumor models to close this gap in knowledge. Enabling biological processes at the cellular level to be ...
    • Towards a point-of-care strip test to diagnose sickle cell anemia 

      Bond, Meaghan; Hunt, Brady; Flynn, Bailey; Huhtinen, Petri; Ware, Russell; Richards-Kortum, Rebecca (2017)
      A rapid test to identify patients with sickle cell disease could have important benefits in low-resource settings. Sickle cell anemia (SCA) affects about 300,000 newborns each year, the majority of whom are born in sub-Saharan ...
    • Transcriptional Activation by NFκB Increases Perlecan/HSPG2 Expression in the Desmoplastic Prostate Tumor Microenvironment 

      Warren, Curtis R.; Grindel, Brian J.; Francis, Lewis; Carson, Daniel D.; Farach-Carson, Mary C. (2014)
      Perlecan/HSPG2, a heparan sulfate proteoglycan typically found at tissue borders including those separating epithelia and connective tissue, increases near sites of invasion of primary prostatic tumors as previously shown ...
    • Tumor Budding: The Name is EMT. Partial EMT. 

      Grigore, Alexandru Dan; Jolly, Mohit Kumar; Jia, Dongya; Farach-Carson, Mary C.; Levine, Herbert (2016)
      Tumor budding is a histological phenomenon encountered in various cancers, whereby individual malignant cells and/or small clusters of malignant cells are seen in the tumor stroma. Postulated to be mirror epithelial-mesenchymal ...
    • Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism 

      Zhao, Hongyun; Yang, Lifeng; Baddour, Joelle; Achreja, Abhinav; Bernard, Vincent; Moss, Tyler; Marini, Juan C.; Tudawe, Thavisha; Seviour, Elena G.; San Lucas, F. Anthony; Alvarez, Hector; Gupta, Sonal; Maiti, Sourindra N.; Cooper, Laurence; Peehl, Donna; Ram, Prahlad T.; Maitra, Anirban; Nagrath, Deepak (2016)
      Cancer-associated fibroblasts (CAFs) are a major cellular component of tumor microenvironment in most solid cancers. Altered cellular metabolism is a hallmark of cancer, and much of the published literature has focused on ...
    • Tunable optical tweezers for wavelength-dependent measurements 

      Hester, Brooke; Campbell, Gretchen K.; Lopez-Mariscal, Carlos; Filgueira, Carly Levin; Huschka, Ryan; Halas, Naomi J.; Helmerson, Kristian (2012)
      Optical trapping forces depend on the difference between the trap wavelength and the extinction resonances of trapped particles. This leads to a wavelength-dependent trapping force, which should allow for the optimization ...
    • Tunable Protease-Activatable Virus Nanonodes 

      Judd, Justin; Ho, Michelle L.; Tiwari, Abhinav; Gomez, Eric J.; Dempsey, Christopher; Vliet, Kim Van; Igoshin, Oleg A.; Silberg, Jonathan J.; Agbandje-McKenna, Mavis; Suh, Junghae (2014)
      We explored the unique signal integration properties of the self-assembling 60-mer protein capsid of adeno-associated virus (AAV), a clinically proven human gene therapy vector, by engineering proteolytic regulation of ...
    • Tuning Hydrogel Properties to Promote the Assembly of Salivary Gland Spheroids in 3D 

      Ozdemir, Tugba; Fowler, Eric W.; Liu, Shuang; Harrington, Daniel A.; Witt, Robert L.; Farach-Carson, Mary C.; Pradhan-Bhatt, Swati; Jia, Xinqiao (2016)
      Current treatments for chronic xerostomia, or “dry mouth”, do not offer long-term therapeutic benefits for head and neck cancer survivors previously treated with curative radiation. Towards the goal of creating tissue-engineered ...
    • Two-Step Self-Assembly of Liposome-Multidomain Peptide Nanofiber Hydrogel for Time-Controlled Release 

      Wickremasinghe, Navindee C.; Kumar, Vivek A.; Hartgerink, Jeffrey D. (2014)
      Progress in self-assembly and supramolecular chemistry has been directed toward obtaining macromolecular assemblies with higher degrees of complexity, simulating the highly structured environment in natural systems. One ...