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  • Single-molecule force measurements of the polymerizing dimeric subunit of von Willebrand factor 

    Wijeratne, Sithara S.; Li, Jingqiang; Yeh, Hui-Chun; Nolasco, Leticia; Zhou, Zhou; Bergeron, Angela; Frey, Eric W.; Moake, Joel L.; Dong, Jing-fei; Kiang, Ching-Hwa (2016)
    Von Willebrand factor (VWF) multimers are large adhesive proteins that are essential to the initiation of hemostatic plugs at sites of vascular injury. The binding of VWF multimers to platelets, as well as VWF proteolysis, ...
  • A Nanostructured Synthetic Collagen Mimic for Hemostasis 

    Kumar, Vivek A.; Taylor, Nichole L.; Jalan, Abhishek A.; Hwang, Lyahn K.; Wang, Benjamin K.; Hartgerink, Jeffrey D. (2014)
    Collagen is a major component of the extracellular matrix and plays a wide variety of important roles in blood clotting, healing, and tissue remodeling. Natural, animal derived, collagen is used in many clinical applications ...
  • Aptamer-Targeted Gold Nanoparticles As Molecular-Specific Contrast Agents for Reflectance Imaging 

    Javier, David J.; Nitin, Nitin; Levy, Matthew; Ellington, Andrew; Richards-Kortum, Rebecca (2008)
    Targeted metallic nanoparticles have shown potential as a platform for development of molecular-specific contrast agents. Aptamers have recently been demonstrated as ideal candidates for molecular targeting applications. ...
  • Open-Source Selective Laser Sintering (OpenSLS) of Nylon and Biocompatible Polycaprolactone 

    Kinstlinger, Ian S.; Bastian, Andreas; Paulsen, Samantha J.; Hwang, Daniel H.; Ta, Anderson H.; Yalacki, David R.; Schmidt, Tim; Miller, Jordan S. (2016)
    Selective Laser Sintering (SLS) is an additive manufacturing process that uses a laser to fuse powdered starting materials into solid 3D structures. Despite the potential for fabrication of complex, high-resolution structures ...
  • Non-monotonic Response to Monotonic Stimulus: Regulation of Glyoxylate Shunt Gene-Expression Dynamics inᅠ Mycobacterium tuberculosis 

    Ascensao, Joao A.; Datta, Pratik; Hancioglu, Baris; Sontag, Eduardo; Gennaro, Maria L.; Igoshin, Oleg A. (2016)
    Understanding how dynamical responses of biological networks are constrained by underlying network topology is one of the fundamental goals of systems biology. Here we employ monotone systems theory to formulate a theorem ...
  • Controlled delivery of β-globin-targeting TALENs and CRISPR/Cas9 into mammalian cells for genome editing using microinjection 

    Cottle, Renee N.; Lee, Ciaran M.; Archer, David; Bao, Gang (2015)
    Tal-effector nucleases (TALEN) and clustered regularly interspaced short palindromic repeats (CRISPR) with CRISPR-associated (Cas) proteins are genome editing tools with unprecedented potential. However, the ability to ...
  • Laminin Peptide-Immobilized Hydrogels Modulate Valve Endothelial Cell Hemostatic Regulation 

    Balaoing, Liezl Rae; Post, Allison Davis; Lin, Adam Yuh; Tseng, Hubert; Moake, Joel L.; Grande-Allen, K. Jane (2015)
    Valve endothelial cells (VEC) have unique phenotypic responses relative to other types of vascular endothelial cells and have highly sensitive hemostatic functions affected by changes in valve tissues. Furthermore, effects ...
  • Design of a New Type of Compact Chemical Heater for Isothermal Nucleic Acid Amplification 

    Shah, Kamal G.; Guelig, Dylan; Diesburg, Steven; Buser, Joshua; Burton, Robert; LaBarre, Paul; Richards-Kortum, Rebecca; Weigl, Bernhard (2015)
    Previous chemical heater designs for isothermal nucleic acid amplification have been based on solid-liquid phase transition, but using this approach, developers have identified design challenges en route to developing a ...
  • Improved Angiogenesis in Response to Localized Delivery of Macrophage-Recruiting Molecules 

    Hsu, Chih-Wei; Poché, Ross A.; Saik, Jennifer E.; Ali, Saniya; Wang, Shang; Yosef, Nejla; Calderon, Gisele A.; Scott, Larry Jr.; Vadakkan, Tegy J.; Larina, Irina V.; West, Jennifer L.; Dickinson, Mary E. (2015)
    Successful engineering of complex organs requires improved methods to promote rapid and stable vascularization of artificial tissue scaffolds. Toward this goal, tissue engineering strategies utilize the release of ...
  • Genetic and Chemical Activation of TFEB Mediates Clearance of Aggregated α-Synuclein 

    Kilpatrick, Kiri; Zeng, Yimeng; Hancock, Tommy; Segatori, Laura (2015)
    Aggregation of α-synuclein (α-syn) is associated with the development of a number of neurodegenerative diseases, including Parkinson’s disease (PD). The formation of α-syn aggregates results from aberrant accumulation of ...
  • Coupling the modules of EMT and stemness: A tunable ‘stemness window’ model 

    Jolly, Mohit Kumar; Jia, Dongya; Boareto, Marcelo; Mani, Sendurai A.; Pienta, Kenneth J.; Ben-Jacob, Eshel; Levine, Herbert (2015)
    Metastasis of carcinoma involves migration of tumor cells to distant organs and initiate secondary tumors. Migration requires a complete or partial Epithelial-to-Mesenchymal Transition (EMT), and tumor-initiation requires ...
  • Deformable complex network for refining low-resolution X-ray structures 

    Zhang, Chong; Wang, Qinghua; Ma, Jianpeng (2015)
    In macromolecular X-ray crystallography, building more accurate atomic models based on lower resolution experimental diffraction data remains a great challenge. Previous studies have used a deformable elastic network (DEN) ...
  • Mechanism for Collective Cell Alignment inᅠ Myxococcus xanthus Bacteria 

    Balagam, Rajesh; Igoshin, Oleg A. (2015)
    Myxococcus xanthusᅠcells self-organize into aligned groups, clusters, at various stages of their lifecycle. Formation of these clusters is crucial for the complex dynamic multi-cellular behavior of these bacteria. However, ...
  • Evolution of the ᅠPerlecan/HSPG2ᅠ Gene and Its Activation in Regeneratingᅠ Nematostella vectensis 

    Warren, Curtis R.; Kassir, Elias; Spurlin, James; Martinez, Jerahme; Putnam, Nicholas H.; Farach-Carson, Mary C. (2015)
    The heparan sulfate proteoglycan 2 (HSPG2)/perlecan gene is ancient and conserved in all triploblastic species. Its presence maintains critical cell boundaries in tissue and its large (up to ~900 kDa) modular structure has ...
  • Prostate cancer and neuroendocrine differentiation: more neuronal, less endocrine? 

    Grigore, Alexandru Dan; Ben-Jacob, Eshel; Farach-Carson, Mary C. (2015)
    Neuroendocrine differentiation (NED) marks a structural and functional feature of certain cancers, including prostate cancer (PCa), whereby the malignant tissue contains a significant proportion of cells displaying neuronal, ...
  • Implications of the hybrid epithelial/mesenchymal phenotype in metastasis 

    Jolly, Mohit Kumar; Boareto, Marcelo; Huang, Bin; Jia, Dongya; Lu, Mingyang; Ben-Jacob, Eshel; Onuchic, José N.; Levine, Herbert (2015)
    Transitions between epithelial and mesenchymal phenotypes - the epithelial to -mesenchymal transition (EMT) and its reverse the mesenchymal to epithelial transition (MET) - are hallmarks of cancer metastasis. While ...
  • Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma 

    Chen, Yulong; Terajima, Masahiko; Yang, Yanan; Sun, Li; Ahn, Young-Ho; Pankova, Daniela; Puperi, Daniel S.; Watanabe, Takeshi; Kim, Min P.; Blackmon, Shanda H.; Rodriguez, Jaime; Liu, Hui; Behrens, Carmen; Wistuba, Ignacio I.; Minelli, Rosalba; Scott, Ken (2015)
    Epithelial tumor metastasis is preceded by an accumulation of collagen cross-links that heighten stromal stiffness and stimulate the invasive properties of tumor cells. However, the biochemical nature of collagen cross-links ...
  • Periodic Migration in a Physical Model of Cells on Micropatterns 

    Camley, Brian A.; Zhao, Yanxiang; Li, Bo; Levine, Herbert; Rappel, Wouter-Jan (2013)
    We extend a model for the morphology and dynamics of a crawling eukaryotic cell to describe cells on micropatterned substrates. This model couples cell morphology, adhesion, and cytoskeletal flow in response to active ...
  • Refactoring and Optimization of Light-Switchable Escherichia coli Two-Component Systems 

    Schmidl, Sebastian R.; Sheth, Ravi U.; Wu, Andrew; Tabor, Jeffrey J. (2014)
    Light-switchable proteins enable unparalleled control of molecular biological processes in live organisms. Previously, we have engineered red/far-red and green/red photoreversible two-component signal transduction systems ...
  • Quasispecies theory for evolution of modularity 

    Park, Jeong-Man; Niestemski, Liang Ren; Deem, Michael W. (2015)
    Biological systems are modular, and this modularity evolves over time and in different environments. A number of observations have been made of increased modularity in biological systems under increased environmental ...

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