Now showing items 1-2 of 2

    • Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity 

      Schönegge, Anne-Marie; Gallion, Jonathan; Picard, Louis-Philippe; Wilkins, Angela D.; Le Gouill, Christian; Audet, Martin; Stallaert, Wayne; Lohse, Martin J.; Kimmel, Marek; Lichtarge, Olivier; Bouvier, Michel (2017)
      Functional selectivity of G-protein-coupled receptors is believed to originate from ligand-specific conformations that activate only subsets of signaling effectors. In this study, to identify molecular motifs playing ...
    • Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity 

      Schönegge, Anne-Marie; Gallion, Jonathan; Picard, Louis-Philippe; Wilkins, Angela D.; Gouill, Christian Le; Audet, Martin; Stallaert, Wayne; Lohse, Martin J.; Kimmel, Marek; Lichtarge, Olivier; Bouvier, Michel (2017)
      Functional selectivity of G-protein-coupled receptors is believed to originate from ligand-specific conformations that activate only subsets of signaling effectors. In this study, to identify molecular motifs playing ...