Now showing items 3875-3894 of 4089

    • Trust-Region Interior-Point SQP Algorithms for a Class of Nonlinear Programming Problems 

      Dennis, J.E.; Heinkenschloss, Matthias; Vicente, Luís N. (1994-12)
      In this paper a family of trust-region interior-point SQP algorithms for the solution of minimization problems with nonlinear equality constraints and simple bounds on some of the variables is described and analyzed. Such ...
    • Tumor Budding: The Name is EMT. Partial EMT. 

      Grigore, Alexandru Dan; Jolly, Mohit Kumar; Jia, Dongya; Farach-Carson, Mary C.; Levine, Herbert (2016)
      Tumor budding is a histological phenomenon encountered in various cancers, whereby individual malignant cells and/or small clusters of malignant cells are seen in the tumor stroma. Postulated to be mirror epithelial-mesenchymal ...
    • Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism 

      Zhao, Hongyun; Yang, Lifeng; Baddour, Joelle; Achreja, Abhinav; Bernard, Vincent; Moss, Tyler; Marini, Juan C.; Tudawe, Thavisha; Seviour, Elena G.; San Lucas, F. Anthony; Alvarez, Hector; Gupta, Sonal; Maiti, Sourindra N.; Cooper, Laurence; Peehl, Donna; Ram, Prahlad T.; Maitra, Anirban; Nagrath, Deepak (2016)
      Cancer-associated fibroblasts (CAFs) are a major cellular component of tumor microenvironment in most solid cancers. Altered cellular metabolism is a hallmark of cancer, and much of the published literature has focused on ...
    • Tunable Lattice Coupling of Multipole Plasmon Modes and Near-Field Enhancement in Closely Spaced Gold Nanorod Arrays 

      Huang, Yu; Zhang, Xian; Ringe, Emilie; Hou, Mengjing; Ma, Lingwei; Zhang, Zhengjun (2016)
      Considering the nanogap and lattice effects, there is an attractive structure in plasmonics: closely spaced metallic nanoarrays. In this work, we demonstrate experimentally and theoretically the lattice coupling of multipole ...
    • Tunable optical tweezers for wavelength-dependent measurements 

      Hester, Brooke; Campbell, Gretchen K.; Lopez-Mariscal, Carlos; Filgueira, Carly Levin; Huschka, Ryan; Halas, Naomi J.; Helmerson, Kristian (2012)
      Optical trapping forces depend on the difference between the trap wavelength and the extinction resonances of trapped particles. This leads to a wavelength-dependent trapping force, which should allow for the optimization ...
    • Tunable Protease-Activatable Virus Nanonodes 

      Judd, Justin; Ho, Michelle L.; Tiwari, Abhinav; Gomez, Eric J.; Dempsey, Christopher; Vliet, Kim Van; Igoshin, Oleg A.; Silberg, Jonathan J.; Agbandje-McKenna, Mavis; Suh, Junghae (2014)
      We explored the unique signal integration properties of the self-assembling 60-mer protein capsid of adeno-associated virus (AAV), a clinically proven human gene therapy vector, by engineering proteolytic regulation of ...
    • Tunable Surface Properties of Aluminum Oxide Nanoparticles from Highly Hydrophobic to Highly Hydrophilic 

      Al-Shatty, Wafaa; Lord, Alex M.; Alexander, Shirin; Barron, Andrew R. (2017)
      The formation of materials with tunable wettability is important for applications ranging from antifouling to waterproofing surfaces. We report the use of various low-cost and nonhazardous hydrocarbon materials to tune the ...
    • Tunable Surface Properties of Aluminum Oxide Nanoparticles from Highly Hydrophobic to Highly Hydrophilic 

      Al-Shatty, Wafaa; Lord, Alex M.; Alexander, Shirin; Barron, Andrew R. (2017)
      The formation of materials with tunable wettability is important for applications ranging from antifouling to waterproofing surfaces. We report the use of various low-cost and nonhazardous hydrocarbon materials to tune the ...
    • Tuning forks with optimized geometries for quartz-enhanced photoacoustic spectroscopy 

      Patimisco, Pietro; Sampaolo, Angelo; Giglio, Marilena; dello Russo, Stefano; Mackowiak, Verena; Rossmadl, Hubert; Cable, Alex; Tittel, Frank K.; Spagnolo, Vincenzo (2019)
      We report on the design, realization, and performance of novel quartz tuning forks (QTFs) optimized for quartz-enhanced photoacoustic spectroscopy (QEPAS). Starting from a QTF geometry designed to provide a fundamental ...
    • Tuning Hydrogel Properties to Promote the Assembly of Salivary Gland Spheroids in 3D 

      Ozdemir, Tugba; Fowler, Eric W.; Liu, Shuang; Harrington, Daniel A.; Witt, Robert L.; Farach-Carson, Mary C.; Pradhan-Bhatt, Swati; Jia, Xinqiao (2016)
      Current treatments for chronic xerostomia, or “dry mouth”, do not offer long-term therapeutic benefits for head and neck cancer survivors previously treated with curative radiation. Towards the goal of creating tissue-engineered ...
    • Tuning support vector machines for minimax and Neyman-Pearson classification 

      Scott, Clayton D.; Baraniuk, Richard G.; Davenport, Mark A. (2008-08-19)
      This paper studies the training of support vector machine (SVM) classifiers with respect to the minimax and Neyman-Pearson criteria. In principle, these criteria can be optimized in a straightforward way using a cost-sensitive ...
    • Tuning the acoustic frequency of a gold nanodisk through its adhesion layer 

      Chang, Wei-Shun; Wen, Fangfang; Chakraborty, Debadi; Su, Man-Nung; Zhang, Yue; Shuang, Bo; Nordlander, Peter; Sader, John E.; Halas, Naomi J.; Link, Stephan (2015)
      To fabricate robust metallic nanostructures with top-down patterning methods such as electron-beam lithography, an initial nanometer-scale layer of a second metal is deposited to promote adhesion of the metal of interest. ...
    • Tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors 

      Chen, Ye; Ho, Joanne M. L.; Shis, David L.; Gupta, Chinmaya; Long, James; Wagner, Daniel S.; Ott, William; Josić, Krešimir; Bennett, Matthew R. (2018)
      One challenge for synthetic biologists is the predictable tuning of genetic circuit regulatory components to elicit desired outputs. Gene expression driven by ligand-inducible transcription factor systems must exhibit the ...
    • Tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors 

      Chen, Ye; Ho, Joanne M.L.; Shis, David L.; Gupta, Chinmaya; Long, James; Wagner, Daniel S.; Ott, William; Josić, Krešimir; Bennett, Matthew R. (2018)
      One challenge for synthetic biologists is the predictable tuning of genetic circuit regulatory components to elicit desired outputs. Gene expression driven by ligand-inducible transcription factor systems must exhibit the ...
    • Tunneling noise and defects in exfoliated hexagonal boron nitride 

      Zhao, Xuanhan; Zhou, Panpan; Chen, Liyang; Watanabe, Kenji; Taniguchi, Takashi; Natelson, Douglas (2019)
      Hexagonal boron nitride (hBN) has become a mainstay as an insulating barrier in stackable nanoelectronics because of its large bandgap and chemical stability. At mono- and bilayer thicknesses, hBN can function as a tunnel ...
    • Turbocharger turbine and exhaust manifold flow computation with the Space-Time Variational Multiscale Method and Isogeometric Analysis 

      Otoguro, Yuto; Takizawa, Kenji; Tezduyar, Tayfun E.; Nagaoka, Kenichiro; Mei, Sen (2019)
      We address the computational challenges encountered in turbocharger turbine and exhaust manifold flow analysis. The core computational method is the Space–Time Variational Multiscale (ST-VMS) method, and the other key ...
    • Two distinctive energy migration pathways of monolayer molecules on metal nanoparticle surfaces 

      Li, Jiebo; Qian, Huifeng; Chen, Hailong; Zhao, Zhun; Yuan, Kaijun; Chen, Guangxu; Miranda, Andrea; Guo, Xunmin; Chen, Yajing; Zheng, Nanfeng; Wong, Michael S.; Zheng, Junrong (2016)
      Energy migrations at metal nanomaterial surfaces are fundamentally important to heterogeneous reactions. Here we report two distinctive energy migration pathways of monolayer adsorbate molecules on differently sized metal ...
    • Two-dimensional lithium diffusion behavior and probable hybrid phase transformation kinetics in olivine lithium iron phosphate 

      Hong, Liang; Li, Linsen; Chen-Wiegart, Yuchen-Karen; Wang, Jiajun; Xiang, Kai; Gan, Liyang; Li, Wenjie; Meng, Fei; Wang, Fan; Wang, Jun; Chiang, Yet-Ming; Jin, Song; Tang, Ming (2017)
      Olivine lithium iron phosphate is a technologically important electrode material for lithium-ion batteries and a model system for studying electrochemically driven phase transformations. Despite extensive studies, many ...
    • Two-Grid Methods for Mixed Finite Element Approximations of Nonlinear Parabolic Equations 

      Dawson, Clint N.; Wheeler, Mary F. (1994-01)
      Mixed finite element approximation of nonlinear parabolic equations is discussed. The equation considered is a prototype of a model which arises in flow through porous media. A two-grid approximation scheme is developed ...
    • Two-pattern compound photonic crystals with a large complete photonic band gap 

      Jia, Lin; Thomas, Edwin L. (2011)
      We present a set of two-dimensional aperiodic structures with a large complete photonic band gap (PBG), which are named two-pattern photonic crystals. By superposing two substructures without regard to registration, we ...