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Effect of nonsteroidal anti-inflammatory drugs on the mechanical and electrical stability of phospholipid membranes
Non-steroidal anti-inflammatory drugs (NSAIDs) display powerful anti-inflammatory, analgesic and anti-pyretic activities. Serious side effects of NSAIDs, such as gastrointestinal (GI) bleeding and peptic ulcer disease, ...
Ab initio methods for protein structure prediction
Recent breakthroughs in DNA and protein sequencing have unlocked many secrets of molecular biology. A complete understanding of gene function, however, requires a protein structure in addition to its sequence. Modern protein ...
Crystallographic refinement of thermal parameters using normal modes
We have developed a software package that models the anisotropic temperature factors of protein structures derived from crystallographic data using normal mode vectors. We hypothesize that the intrinsic flexibility of a ...