Now showing items 1-6 of 6
Polymeric delivery of inhibitors of smooth muscle cell proliferation
Restenosis, currently estimated to occur in 30-50% of dilated lesions, continues to be a major limitation to the success of current interventional cardiovascular procedures. Presently, no established therapy prevents or ...
2D timelapse and 3D fluorescence microscopy with applications to vascular tissue engineering
Part of the definition given to the new emerging science discipline of tissue engineering is the understanding of the structure-function relationships at the cellular level. In this context it is important for vascular ...
Hydrodynamic and molecular dependence of neutrophil-neutrophil adhesion
Homotypic adhesion of neutrophils stimulated with chemoattractant is analogous to capture on vascular endothelium in that both processes depend on L-selectin and $\beta\sb2$-integrin adhesion receptors. Under hydrodynamic ...
Development of poly(propylene fumarate-co-ethylene glycol): An injectable, biodegradable implant for cardiovascular applications
A novel block copolymer consisting of poly(propylene fumarate), PPF, and poly(ethylene glycol), PEG, was fabricated and evaluated for use as a cardiovascular stent to prevent reclosure of the vessel lumen following balloon ...
Molecular mechanisms of platelet thrombosis under arterial shear conditions
Pathologic arterial thrombosis is the leading cause of death in many countries. Current therapies provide only moderate protection from heart attack, stroke, and other clinical manifestations of thrombosis. To develop more ...
Injectable, in situ polymerizable, biodegradable scaffolds based on poly(propylene fumarate) for guided bone regeneration
Poly(propylene fumarate) (PPF) was developed as a scaffold to guide bone regeneration. Synthesis of this material via refined reaction pathways led to increased purity and higher molecular weights of this unsaturated, ...