Now showing items 1-5 of 5
Stability and specificity of transmembrane domain self-association by mutagenesis and protein design
Stability and specificity of transmembrane domain self-association by In this thesis, I investigate the sequence dependence of homodimerization of the transmembrane domain of the pro-apoptotic C. elegans protein BNIP3. ...
Insights into peroxisome matrix protein import and IBA metabolism through analysis of IBA-response mutants
Peroxisomes are single membrane-bound organelles that function to compartmentalize certain metabolic reactions critical to plant and animal development. I have studied peroxisomal processes in the model plant Arabidopsis ...
Escort protein regulation of the human mitochondrial molecular chaperone mtHsp70
Mitochondrial Hsp70 molecular chaperones (mtHsp70) are nuclear-encoded proteins that are needed for the import of proteins into the mitochondrial matrix, biogenesis of Fe/S-clusters involved in energy metabolism, and stress ...
The Saccharomyces cerecisiae hsp70 escort protein Hep1 exhibits cross-reactivity with a non-cognate chaperone
Genetic studies have provided evidence that the hsp70 escort protein Hep1 is essential for maintaining the solubility of the mitochondrial chaperones Ssc1 and Ssq1 in Saccharomyces cerevisiae. However, little is known about ...
Characterization of the stimulation of SNARE-mediated membrane fusion by the SM protein Munc18a
The mammalian neuronal Sec1p/Munc18 protein Muncl8a binds tightly to the t-SNARE Syntaxin1a in isolation, and the binary Muncl8a/Syntaxin1a interaction is thought to prevent formation of the Syntaxin1a/SNAP25b t-SNARE ...