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The effects of amino acid substitution on apomyoglobin stability, folding intermediates, and holoprotein expression
The stabilities and expression levels of over 150 randomly-generated triple mutants and 100 different rationally constructed single, double, and triple mutants of sperm whale myoglobin have been examined. The effects of ...
Structural and functional studies of birnavirus RNA polymerases---Insights into the protein-priming mechanism and the evolution of RNA viruses
The first crystal structure of a birnavirus polymerase, IBDV VP1, has been determined at 2.5 A resolution by multiple isomorphous replacement and anomalous scattering (MIR-AS). The VP1 structure reveals several highly ...