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Structural and thermodynamic analysis of human PCNA bound to peptides derived from DNA polymerase-delta p66-subunit and flap endonuclease-1 (FEN1) proteins
DNA replication and repair requires the coordination of multiple proteins at the replication fork. Among the proteins found at the replisome, hPCNA (h&barbelow;uman P&barbelow;roliferating C&barbelow;ell N&barbelow;uclear ...
Biochemical and crystallographic studies of bacteriophage RB69 DNA polymerase and single-stranded DNA binding protein interactions
The organization and proper assembly of proteins to the primer-template junction during DNA replication is essential for accurate and processive DNA synthesis. The DNA replication process in RB69 (a T4-like bacteriophage) ...
Human UP1 as a model for understanding purine recognition in the family of proteins containing the RNA recognition motif (RRM)
Heterogeneous ribonucleoprotein A1 (hnRNP A1) is a prototype for the family of eukaryotic RNA processing proteins containing the common RNA recognition motif (RRM). The region consisting of residues 1--195 of hnRNP Al is ...
Overcoming the challenges of twinning and pseudo symmetry in solving the structure of flavodoxin from Desulfovibrio desulfuricans 29577 by x-ray crystallography
In solving the structure of flavodoxin from Desulfovibrio desulfuricans 29577, crystallographic challenges of twinning and pseudo translational symmetry were encountered. The effects of both challenges were investigated ...