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A density sensing mechanism in the eukaryote Dictyostelium discoideum
I am interested in understanding a mechanism by which multicellular organisms sense number of cells of the same type. The model selected is the conditioned medium factor secreted by Dictyostelium discoideum. In submerged ...
Metabolic characterization of T cell lymphoblastoid, Jurkat, in the presence of respiration inhibitors in a continuous reactor
Commercial scale mammalian cell culture systems have many technical barriers: (i) accumulation of inhibitory waste products; (ii) sensitivity to low level of shear; and (iii) cellular oxygen demand in excess of bioreactor's ...
Density sensing in Dictyostelium discoideum: Evidence for the sequestering of a density sensing factor in the plasma membrane and a role for this factor in cell aggregation
A density sensing factor has been isolated from Dictyostelium discoideum and is known as conditioned media factor (CMF). CMF has been shown to cause starved vegetative Dictyostelium cells to differentiate into one of two ...
Effects of cyclical strain on the production of vasoactive materials by cultured human and bovine endothelial cells
Much recent emphasis in vascular biology has focused on endothelial cells which form the inner lining of blood vessels. This unique arterial location exposes these cells directly to mechanical forces resulting from blood ...