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Synthetic studies towards the total synthesis of discorhabdin C
(1994)
Two synthetic approaches towards the total synthesis of discorhabdin C (3) are described. The general strategy for construction of azacarbocyclic spiro dienone system is to employ an intramolecular para-phenolic alkylation ...
Mechanistic investigations of novel, irreversible inhibitors of S-adenosylhomocysteine hydrolase
(1992)
Isolation of bovine S-adenosylhomocysteine hydrolase by affinity chromatography unexpectedly yielded two forms of the enzyme. Type A contained 4 moles of NAD$\sp+$/mole of enzyme tetramer, while Type B had only half that ...
Syntheses, bioactivities and conformations of peptidomimetics containing 2,3-methanoamino acids
(1994)
Asymmetric syntheses of E- and Z-2,3-methanomethionine (ie E- and Z-cyclo-Met), protected Z-2,3-methanoarginine, and Z-2,3-methanoaspartic acid derivatives have been developed. These functionalized 2,3-methanoamino acids ...
Investigations of neplanocin a reductase, an enzyme involved in aristeromycin biosynthesis
(1998)
The nucleoside antibiotics aristeromycin and neplanocin A are two naturally occurring carbocyclic analogs of adenosine produced by Streptomyces citricolor. Partial purification of the crude cell-free extracts of S. citricolor ...
Investigation of valanimycin biosynthesis
(1996)
The antibiotic valanimycin is an azoxy compound produced by Streptomyces viridifaciens MG456-hF10. Precursor incorporation experiments with (4-$\sp{13}$C) -N-(isobutylamino)serine and $\rm \lbrack\sp{15}N\sb2\rbrack$-N-( ...