Now showing items 1-4 of 4
A study of the fluid mechanics and the cultivation of mammalian cells in a magnetically stabilized fluidized bed bioreactor
The culture of anchorage dependent mammalian cells on microcarrier offers an attractive avenue for achieving high productivity of therapeutic and diagnostic proteins in bioreactors. Reducing production costs require high ...
Nonlinear model of external respiration
A mathematical model of the external respiratory system is presented which integrates component models of airway mechanics and gas exchange at the pulmonary capillaries. The respiratory system is lumped into: (1) a conducting ...
Characterization and application of a periplasmic protein releasing system for extracellular recombinant protein production in Escherichia coli
Escherichia coli is commonly used as a host in the production of high value therapeutic proteins. However, one major drawback associated with E. coli being a host is the intracellular location of product proteins. As a ...
Sensitivity analysis of a mechanistic growth model of Escherichia coli
A detailed mechanistic model, with a large number of metabolites and parameters, describing growth of a single cell of the bacterium Escherichia coli is simulated and the resulting predictions are compared with available ...