Now showing items 1-5 of 5
Syntheses, bioactivities and conformations of peptidomimetics containing 2,3-methanoamino acids
Asymmetric syntheses of E- and Z-2,3-methanomethionine (ie E- and Z-cyclo-Met), protected Z-2,3-methanoarginine, and Z-2,3-methanoaspartic acid derivatives have been developed. These functionalized 2,3-methanoamino acids ...
Interaction of a helical peptide with membrane: Study of alamethicin
Alamethicin is a transmembrane ion channel at low concentration, and a lytic agent of cell membrane at high concentration. It is a small size polypeptide (20 amino residues), and contains a large section of amphiphilic ...
The role of mouse adenosine deaminase in purine metabolism: Physiological and mechanistic aspects
Recent studies on the tissue distribution and developmental regulation of ADA activity in mice show that very high ADA levels exist in the murine alimentary tract (tongue, esophagus, forestomach, proximal small intestine) ...
Synthetic studies towards the total synthesis of discorhabdin C
Two synthetic approaches towards the total synthesis of discorhabdin C (3) are described. The general strategy for construction of azacarbocyclic spiro dienone system is to employ an intramolecular para-phenolic alkylation ...
Cloning and characterization of CMF, a density sensing factor in Dictyostelium discoideum
Conditioned medium factor (CMF), is an 80 kD glycoprotein which is the ligand in a cell density sensing system used by developing Dictyostelium discoideum cells. CMF is slowly secreted by cells when they starve, and the ...