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Structural determinants of functional behavior in distal pocket mutants of myoglobin
The physiological role of myoglobin depends on the modulation of heme activity by the protein. The hypothesis that functional properties are governed by conserved residues in the distal pocket has been tested by site-directed ...
Application of metabolic and biochemical engineering techniques for the enhancement of recombinant protein production in Escherichia coli
This study focuses on the application of metabolic engineering techniques to diminish acetate excretion, as a means to enhance recombinant protein productivities. The recombinant model system is based on the formation of ...
Structure of tropomyosin at 7A resolution
The crystal structure of tropomyosin has been determined by X-ray diffraction analysis at 7A resolution. Tropomyosin is a 400A-long muscle regulatory protein that consists of two parallel 33,000 Dalton alpha helices wound ...