Now showing items 1-5 of 5
Syntheses, bioactivities and conformations of peptidomimetics containing 2,3-methanoamino acids
Asymmetric syntheses of E- and Z-2,3-methanomethionine (ie E- and Z-cyclo-Met), protected Z-2,3-methanoarginine, and Z-2,3-methanoaspartic acid derivatives have been developed. These functionalized 2,3-methanoamino acids ...
Transition metal-catalyzed hydroboration
Model studies on rhodium catalyzed hydroborations of sterically unbiased alkenes with catecholborane provided evidence for the role of d$\pi$-p$\pi$ bonding in these transformations. Catalyzed hydroborations of ...
Thermolysis and photolysis of bifunctional initiators: Free radical centers beta to the azo, azoxy and perester groups
Peresters $\beta$ to azo or azoxy groups are potentially interesting bifunctional initiators. They decompose thermally at essentially the same rate as the analogous simple perester. It follows that decomposition occurs ...
Synthetic studies towards the total synthesis of discorhabdin C
Two synthetic approaches towards the total synthesis of discorhabdin C (3) are described. The general strategy for construction of azacarbocyclic spiro dienone system is to employ an intramolecular para-phenolic alkylation ...
Total synthesis of (-)-hapalindole G: A novel tin-mediated indole synthesis
The first total synthesis of ($-$)-hapalindole G, a member of novel chlorine- and isonitrile-containing hapalindoles from the cultured cyanophyte Hapalosiphon fontinalis, is accomplished. Our 21-step synthesis of ...