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Effects of sickle erythrocytes on metabolism and gene regulation in cultured human endothelial cells under flow conditions
Sickle cell anemia is characterized by chronic hemolysis and episodic vasoocclusive crises. There are many factors contributing to vascular occlusion in sickle cell patients, with the enhanced, abnormal adhesion of sickle ...
Analysis of metabolic flux of secondary metabolite pathways in Catharanthus roseus hairy root cultures
Catharanthus roseus, a tropical plant, produces the valuable anti-cancer compounds, vincristine and vinblastine in extremely low amounts. My research objectives were to examine the response of plant secondary metabolism ...
Modulation of cell morphology and function using synthetic biodegradable polymers
Synthetic biodegradable poly(DL-lactic-co-glycolic acid) (PLGA) has been fabricated into thin films for use as scaffolds for cell transplantation and guided tissue regeneration. We evaluated the ability of PLGA films to ...
Interactions of the platelet GP Ib-IX-V complex with immobilized von Willebrand factor under flow conditions
Platelets play key roles in physiology, such as the arrest of bleeding following vascular injury, and in pathology, such as mural arterial thrombosis. The initial step in both processes is platelet adhesion to von Willebrand ...