Now showing items 1-5 of 5
The molecular structure of green fluorescent protein
The crystal structure of recombinant wild-type green fluorescent protein (GFP) has been solved to a resolution of 1.9 A by multiwavelength anomalous dispersion phasing methods using selenomethionyl GFP crystals. The protein ...
Construction and characterization of purine repressor mutants with altered oligomerization states
X-Ray crystallographic structure and deletion mutagenesis of LacI have demonstrated that three-leucine-heptad repeats (LHR3), located at the C-terminus, are critical for dimer-dimer interaction to form tetramer. We are ...
Mechanistic and structural studies of mouse adenosine deaminase
Adenosine deaminase (ADA) catalyzes the irreversible deamination of (2$\sp\prime$-deoxy)adenosine to (2$\sp\prime$-deoxy)inosine. It is an indispensable enzyme, with a role in purine catabolism and in the development of a ...
Structures and interactions of tropomyosin with caldesmon and troponin
Tropomyosin plays a central role in the regulation of skeletal, cardiac, and smooth muscle regulation. The regulatory properties of tropomyosin are mediated by its interactions with muscle-specific tropomyosin binding ...
Reactions of nitric oxide with myoglobin
Nitric oxide (NO) has been implicated as mediator in a variety of physiological functions, including neurotransmission, platelet aggregation, macrophage function, and vasodilation. Mild hypertensive events have been reported ...