Now showing items 1-6 of 6
Impact loading and functional tissue engineering of articular cartilage
This thesis presents two advances for alleviating the problem of articular cartilage degeneration: mitigating degradative changes that follow mechanically induced injuries and growing functional neo-cartilage for diseased ...
Development of bioactive polyurethaneureas to support endothelialization
Vascular diseases are responsible for the majority of deaths in the United States. Synthetic materials have been developed for blood vessel substitutes but not suitable for small diameter vascular applications such as ...
Virtual bioinstrumentation: Integrating biomedical experimentation with systems-level modeling and analysis
This dissertation is a treatise on the merging of biomedical experimentation with modern data acquisition and analysis as an integrated teaching and research platform. Virtual (i.e. computer-based) instrumentation forms ...
Optimization of cryogen spray cooling: Increasing epidermal protection during cutaneous laser procedures
Cryogen spray cooling (CSC) is an effective method to minimize epidermal damage during laser treatment of various cutaneous anomalies such as port wine stains (PWS). We examined the mechanism of heat removal by CSC from ...
Poly(ethylenimine) as a gene delivery vehicle, and its potential for gene therapy
Poly(ethylenimine) (PEI) is a polycation with proven success as a gene delivery vehicle both in vitro and in vivo. The work described herein addresses several aspects of PEI-mediated gene delivery. First, a model system ...
Effects of shear stress and cyclic strain on the expression of thrombin receptor gene in human vascular endothelial and smooth muscle cells
Mechanical forces such as shear stress and cyclic strain have been shown to regulate expression of many genes that can alter vascular functions such as cell proliferation, leading to the development of vascular diseases ...