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Automated tracking of tumor invasion in three dimensional extracellular matrix analogs and a novel stochastic analysis of the cell trajectories
Tumor cell migration and invasion of body tissues are prerequisite mediators for lymphatic or hematogenous cancer dissemination. To date, there is insufficient understanding of what triggers the metastatic cascade, and of ...
Application of metabolic and biochemical engineering techniques to enhance metabolic flux throughput and improve succinate production in Escherichia coli
Using biochemical engineering principles and metabolic engineering tools in tandem can considerably improve process productivity by manipulation of the throughput of certain pathways. Escherichia coli was chosen as the ...
Gene therapy approaches to alter the mechanical properties of tissue-engineered constructs
One of the current issues in the development of a tissue engineered vascular graft is sufficient mechanical strength to erase concerns with burst failure. The goal of this project was to assess the mechanical integrity of ...
A model of the human cardiopulmonary system
This study developed a mathematical model of human cardiopulmonary system which consists of component models such as ventricular mechanics, hemodynamics of the systemic and pulmonic circulations, baroreflex control of ...