Now showing items 1-6 of 6
Quantifying information coding limits in sensory systems
Neurons code information about sensory stimuli temporally in the times of occurrence of action potentials as well as spatially in the joint discharge patterns of neurons within an ensemble. In this work, we present a ...
Interactions of the platelet GP Ib-IX-V complex with immobilized von Willebrand factor under flow conditions
Platelets play key roles in physiology, such as the arrest of bleeding following vascular injury, and in pathology, such as mural arterial thrombosis. The initial step in both processes is platelet adhesion to von Willebrand ...
Modulation of cell morphology and function using synthetic biodegradable polymers
Synthetic biodegradable poly(DL-lactic-co-glycolic acid) (PLGA) has been fabricated into thin films for use as scaffolds for cell transplantation and guided tissue regeneration. We evaluated the ability of PLGA films to ...
Tumor cell adhesion: Dynamic adhesion of RAW117 lymphoma to organ-specific endothelial cells and the development of an invasion assay
The role of cell adhesion molecules was explored in a model of hematogenous metastasis. RAW117 lymphoma cells were perfused over hepatic sinusoidal endothelial (HSE) and murine microvascular lung endothelial (MLE) monolayers ...
Effects of sickle erythrocytes on metabolism and gene regulation in cultured human endothelial cells under flow conditions
Sickle cell anemia is characterized by chronic hemolysis and episodic vasoocclusive crises. There are many factors contributing to vascular occlusion in sickle cell patients, with the enhanced, abnormal adhesion of sickle ...
Analysis of metabolic flux of secondary metabolite pathways in Catharanthus roseus hairy root cultures
Catharanthus roseus, a tropical plant, produces the valuable anti-cancer compounds, vincristine and vinblastine in extremely low amounts. My research objectives were to examine the response of plant secondary metabolism ...