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Tumor cell adhesion stabilization: Regulation and relationship to organ-specific metastasis
Tumor cell arrest and the formation of stable adhesive interactions between tumor cells and endothelial cells or underlying matrix in the microvasculature are crucial steps in the metastatic process. A sensitive hydrodynamic ...
Dynamic mathematical modeling of mural thrombogenesis over type I collagen
We have developed a transient computational model of mural thrombogenesis, simulating whole blood flow in real time in a parallel plate flow chamber. Finite element computational methods were utilized to solve governing ...
Flow induced regulation of endothelial nitric oxide synthase (eNOS) gene expression: Role of shear sensitive promoter elements
Vascular endothelium responds to hemodynamic forces such as shear stress by altering the synthesis and genetic expression of several proteins. Shear stress sensitive promoter elements and transcription factors may be ...
Receptor mediated adhesion of sickle erythrocytes and damage to IL-1 beta stimulated endothelial cells under flow conditions in vitro
Enhanced, abnormal adherence of sickle erythrocytes to the endothelium lining blood vessels is hypothesized to contribute to vasoocclusion in sickle cell patients, but the specific molecular mechanisms by which these ...