Now showing items 131-135 of 135
Reactions of nitric oxide with myoglobin
Nitric oxide (NO) has been implicated as mediator in a variety of physiological functions, including neurotransmission, platelet aggregation, macrophage function, and vasodilation. Mild hypertensive events have been reported ...
Apoglobin stability and ligand movements in mammalian myoglobins
The design of recombinant globins as oxygen storage and delivery pharmaceuticals must address two key protein engineering problems, one dealing with the improvement of apoprotein stability and the other with the structural ...
MAPK pathways of the yeast Saccharomyces cerevisiae: Cell integrity and filamentation/invasion pathway interaction with the hog pathway
Mitogen Activated Protein Kinase (MAPK) cascades are frequently used signal transduction mechanisms in eukaryotes. Of the five MAPK cascade containing signaling pathways in the budding yeast Saccharomyces cerevisiae , the ...
A comparative study of the membrane-active beta-sheet peptide protegrin with the alpha-helical peptide alamethicin
The interactions of the membrane-active peptides alamethicin and protegrin with lipid bilayers are studied. The influence of the bilayer composition on the orientation transition of alamethicin is studied using oriented ...
Examination of the C-terminal assembly motif in lactose repressor
Assembly requirements for lactose repressor protein have been examined by substitutions in the leucine heptad repeat (LHR) tetramerization domain. All a and d positions of the LHR were substituted with Ile (II) or a positions ...